ArticleBiophysical journal2000
Complex voltage-dependent behavior of single unliganded calcium-sensitive potassium channels.
Article in Biophysical journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Lipid gating of BK channels and activation mechanism by negatively charged lipids.Communications chemistry · 2026Article
- The Calcium Signaling Mechanisms in Arterial Smooth Muscle and Endothelial Cells.Comprehensive Physiology · 2021Article
- Analyzing single-molecule time series via nonparametric Bayesian inference.Biophysical journal · 2015Article
- Interfacial gating triad is crucial for electromechanical transduction in voltage-activated potassium channels.The Journal of general physiology · 2014Article
- Single-channel kinetics of BK (Slo1) channels.Frontiers in physiology · 2014Review
- Free-energy relationships in ion channels activated by voltage and ligand.The Journal of general physiology · 2013Article
- A mechanistic description of gating of the human cardiac ryanodine receptor in a regulated minimal environment.The Journal of general physiology · 2012Article
- BK-type calcium-activated potassium channels: coupling of metal ions and voltage sensing.The Journal of physiology · 2010Review
- Intersubunit coupling in the pore of BK channels.The Journal of biological chemistry · 2009Article
- Relationship between pore occupancy and gating in BK potassium channels.The Journal of general physiology · 2006Article
- Differential effects of beta 1 and beta 2 subunits on BK channel activity.The Journal of general physiology · 2005Article
- Protons block BK channels by competitive inhibition with K+ and contribute to the limits of unitary currents at high voltages.The Journal of general physiology · 2004Article
- Gating mechanism of BK (Slo1) channels: so near, yet so far.The Journal of general physiology · 2003Review
- Coupling between voltage sensor activation, Ca2+ binding and channel opening in large conductance (BK) potassium channels.The Journal of general physiology · 2002Article
- Stepwise contribution of each subunit to the cooperative activation of BK channels by Ca2+.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Elimination of the BK(Ca) channel's high-affinity Ca(2+) sensitivity.The Journal of general physiology · 2002Article
- Modeling hair cell tuning by expression gradients of potassium channel beta subunits.Biophysical journal · 2002Article
- Gating and conductance properties of BK channels are modulated by the S9-S10 tail domain of the alpha subunit. A study of mSlo1 and mSlo3 wild-type and chimeric channels.The Journal of general physiology · 2001Article
- Kinetic gating mechanisms for BK channels: when complexity leads to simplicity.The Journal of general physiology · 2001Article
- Inactivation of BK channels mediated by the NH(2) terminus of the beta3b auxiliary subunit involves a two-step mechanism: possible separation of binding and blockade.The Journal of general physiology · 2001Article
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Authors and funding
2 authors.
Funding
Abstract
study and characterization of unliganded openings is of central significance for the elucidation of gating mechanisms for allosteric ligand-gated ion channels. Unliganded openings have been reported for many channel types, but their low open probability can make it difficult to study their kinetics in detail. Because the large conductance calcium-activated potassium channel mSlo is sensitive to both intracellular calcium and to membrane potential, we have been able to obtain stable unliganded single-channel recordings of mSlo with relatively high opening probability. We have found that the single-channel gating behavior of mSlo is complex, with multiple open and closed states, even when no ligand is present. Our results rule out a Monod-Wyman-Changeux allosteric mechanism with a central voltage-dependent concerted step, and they support the existence of quaternary states with less than the full number of voltage sensors activated, as has been suggested by previous work involving measurements of gating currents.
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