ArticleGenes & development2000
Mechanisms of Hox gene colinearity: transposition of the anterior Hoxb1 gene into the posterior HoxD complex.
Article in Genes & development, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 96 citations in OpenAlex.
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- Control of growth and gut maturation byProceedings of the National Academy of Sciences of the United States of America · 2017Article
- A Complex Structural Variation on Chromosome 27 Leads to the Ectopic Expression of HOXB8 and the Muffs and Beard Phenotype in Chickens.PLoS genetics · 2016Article
- Role of abd-A and Abd-B in development of abdominal epithelia breaks posterior prevalence rule.PLoS genetics · 2014Article
- Mechanisms and constraints shaping the evolution of body plan segmentation.The European physical journal. E, Soft matter · 2013Article
- Hoxc gene collinear expression and epigenetic modifications established during embryogenesis are maintained until after birth.International journal of biological sciences · 2013Article
- Evo-Devo of the Human Vertebral Column: On Homeotic Transformations, Pathologies and Prenatal Selection.Evolutionary biology · 2012Article
- Recruitment of 5' Hoxa genes in the allantois is essential for proper extra-embryonic function in placental mammals.Development (Cambridge, England) · 2012Article
- Structural dynamics and epigenetic modifications of Hoxc loci along the anteroposterior body axis in developing mouse embryos.International journal of biological sciences · 2012Article
- Evolution of networks for body plan patterning; interplay of modularity, robustness and evolvability.PLoS computational biology · 2011Article
- Annelid Distal-less/Dlx duplications reveal varied post-duplication fates.BMC evolutionary biology · 2011Article
- Review
- Controlled somatic and germline copy number variation in the mouse model.Current genomics · 2010Article
- Establishment of Hox vertebral identities in the embryonic spine precursors.Current topics in developmental biology · 2009Review
- Ectopic nuclear reorganisation driven by a Hoxb1 transgene transposed into Hoxd.Journal of cell science · 2008Article
- Distinct roles and regulations for HoxD genes in metanephric kidney development.PLoS genetics · 2007Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transposition of Hoxd genes to a more posterior (5') location within the HoxD complex suggested that colinearity in the expression of these genes was due, in part, to the existence of a silencing mechanism originating at the 5' end of the cluster and extending towards the 3' direction. To assess the strength and specificity of this repression, as well as to challenge available models on colinearity, we inserted a Hoxb1/lacZ transgene within the posterior HoxD complex, thereby reconstructing a cluster with a copy of the most anterior gene inserted at the most posterior position. Analysis of Hoxb1 expression after ectopic relocation revealed that Hoxb1-specific activity in the fourth rhombomere was totally abolished. Treatment with retinoic acid, or subsequent relocations toward more 3' positions in the HoxD complex, did not release this silencing in hindbrain cells. In contrast, however, early and anterior transgene expression in the mesoderm was unexpectedly not suppressed. Furthermore, the transgene induced a transient ectopic activation of the neighboring Hoxd13 gene, without affecting other genes of the complex. Such a local and transient break in colinearity was also observed after transposition of the Hoxd9/lacZ reporter gene, indicating that it may be a general property of these transgenes when transposed at an ectopic location. These results are discussed in the context of existing models, which account for colinear activation of vertebrate Hox genes.
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10652274PMC316340W2145415222What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.