ArticleGenes & development2000
Rhomboid and Star facilitate presentation and processing of the Drosophila TGF-alpha homolog Spitz.
Article in Genes & development, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed.
- miR-9a regulates levels of both rhomboid mRNA and protein in the early Drosophila melanogaster embryo.G3 (Bethesda, Md.) · 2022Article
- Degenerate Pax2 and Senseless binding motifs improve detection of low-affinity sites required for enhancer specificity.PLoS genetics · 2018Article
- Identifying pathways modulating sleep duration: from genomics to transcriptomics.Scientific reports · 2017Article
- RHBDD1 upregulates EGFR via the AP-1 pathway in colorectal cancer.Oncotarget · 2017Article
- Epidermal Growth Factor Pathway Signaling in Drosophila Embryogenesis: Tools for Understanding Cancer.Cancers · 2017Review
- Mapping signaling pathway cross-talk in Drosophila cells.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Rhomboids, signalling and cell biology.Biochemical Society transactions · 2016Review
- Rhomboid domain containing 1 promotes colorectal cancer growth through activation of the EGFR signalling pathway.Nature communications · 2015Article
- RTK signaling modulates the Dorsal gradient.Development (Cambridge, England) · 2012Article
- rhomboid mediates specification of blue- and green-sensitive R8 photoreceptor cells in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- The role of protease activity in ErbB biology.Experimental cell research · 2009Review
- Dynein and Star interact in EGFR signaling and ligand trafficking.Journal of cell science · 2008Article
- Presenilin-based genetic screens in Drosophila melanogaster identify novel notch pathway modifiers.Genetics · 2006Article
- EGF signal propagation during C. elegans vulval development mediated by ROM-1 rhomboid.PLoS biology · 2004Article
- Regulation of the Drosophila epidermal growth factor-ligand vein is mediated by multiple domains.Genetics · 2004Article
- Long-range signal transmission in autocrine relays.Biophysical journal · 2003Article
- A fly's eye view of EGF receptor signalling.The EMBO journal · 2002Article
- A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands.The EMBO journal · 2002Article
- Keren, a new ligand of the Drosophila epidermal growth factor receptor, undergoes two modes of cleavage.The EMBO journal · 2002Article
- Expression in mammalian cell cultures reveals interdependent, but distinct, functions for Star and Rhomboid proteins in the processing of the Drosophila transforming-growth-factor-alpha homologue Spitz.The Biochemical journal · 2002Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Activation of the Drosophila epidermal growth factor receptor (DER) by the transmembrane ligand, Spitz (Spi), requires two additional transmembrane proteins, Rhomboid and Star. Genetic evidence suggests that Rhomboid and Star facilitate DER signaling by processing membrane-bound Spi (mSpi) to an active, soluble form. To test this model, we use an assay based on Xenopus animal cap explants in which Spi activation of DER is Rhomboid and Star dependent. We show that Spi is on the cell surface but is kept in an inactive state by its cytoplasmic and transmembrane domains; Rhomboid and Star relieve this inhibition, allowing Spi to signal. We show further that Spi is likely to be cleaved within its transmembrane domain. However, a mutant form of mSpi that is not cleaved still signals to DER in a Rhomboid and Star-dependent manner. These results suggest strongly that Rhomboid and Star act primarily to present an active form of Spi to DER, leading secondarily to the processing of Spi into a secreted form.
Indexed as
Identifiers
10652272PMC316351What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.