ArticleImmunology2000
Cellular interactions in bovine tuberculosis: release of active mycobacteria from infected macrophages by antigen-stimulated T cells.
Article in Immunology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 34 citations in OpenAlex.
- Real-time PCR using atpE, conventional PCR targeting different regions of difference, and flow cytometry for confirmation of Mycobacterium bovis in buffaloes and cattle from the Delta area of Egypt.BMC microbiology · 2022Article
- Evaluation of the Presence and Viability ofFoods (Basel, Switzerland) · 2021Article
- Identifying Bacterial and Host Factors Involved in the Interaction ofFrontiers in immunology · 2021Article
- Genome-wide transcriptional profiling of peripheral blood leukocytes from cattle infected with Mycobacterium bovis reveals suppression of host immune genes.BMC genomics · 2011Article
- Comparison of different testing schemes to increase the detection Mycobacterium bovis infection in Ethiopian cattle.Tropical animal health and production · 2010Article
- Gamma-delta T cell subsets are differentially associated with granuloma development and organization in a bovine model of mycobacterial disease.International journal of experimental pathology · 2009Article
- Cytotoxic T-cell responses to Mycobacterium bovis during experimental infection of cattle with bovine tuberculosis.Immunology · 2003Article
- Investigation of the role of CD8+ T cells in bovine tuberculosis in vivo.Infection and immunity · 2003Article
- Modulation of immune responses to Mycobacterium bovis in cattle depleted of WC1(+) gamma delta T cells.Infection and immunity · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The outcome of Mycobacterium bovis infections depends on the interactions of infected macrophages with T lymphocytes. Several studies in humans and in mouse models have suggested an important role for cytotoxicity in the protective immune response to mycobacterial infections, and both CD4+ and CD8+ T cells have been shown to elicit appropriate cytolytic activity. The present study investigated in vitro interactions of T cells with M. bovis-infected macrophages in bovine tuberculosis. The results showed that following interaction with antigen-stimulated peripheral blood mononuclear cells (PBMC) from infected cattle, there was an increased presence of M. bovis in the extracellular compartment of infected macrophage cultures, as measured by incorporation of [3H]uracil into mycobacterial RNA. Furthermore, out of a panel of T-cell clones from infected cattle, it was found that a higher proportion of CD8+ clones produced an increase in the number of metabolically active extracellular M. bovis organisms compared with CD4+ clones. Finally, a positive correlation between percentage of antigen-dependent release of mycobacteria and total uracil uptake by M. bovis within culture systems was detected. This could be regarded as an indication of preferential intracellular control of mycobacteria by activated macrophages.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.