ArticleBMJ (Clinical research ed.)2000
Risk of cardiovascular disease measured by carotid intima-media thickness at age 49-51: lifecourse study.
Article in BMJ (Clinical research ed.), 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 163 citations in OpenAlex.
- Dimensions of early life adversity and cardiometabolic health in adulthood: A systematic review and meta-analysis.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026Pooled it
- Childhood obesity and risk of the adult metabolic syndrome: a systematic review.International journal of obesity (2005) · 2012Pooled it
- Evaluating the evidence for models of life course socioeconomic factors and cardiovascular outcomes: a systematic review.BMC public health · 2005Pooled it
- Prospective links between childhood family income and subclinical atherosclerosis in a sample of young men.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026Article
- Evaluation of carotid intima media thickness measurement from ultrasound images.Medical & biological engineering & computing · 2022Article
- Light-To-Moderate Raw Garlic Consumption Frequency Is Inversely Associated With Thickened Carotid Intima-Media Thickness: A Population-Based Study.Frontiers in nutrition · 2021Article
- Natural History of Atherosclerosis and Abdominal Aortic Intima-Media Thickness: Rationale, Evidence, and Best Practice for Detection of Atherosclerosis in the Young.Journal of clinical medicine · 2019Review
- Intrauterine growth restriction results in persistent vascular mismatch in adulthood.The Journal of physiology · 2018Article
- The association between socioeconomic status and subclinical atherosclerosis in a rural Bangladesh population.Preventive medicine · 2017Article
- Accurate lumen diameter measurement in curved vessels in carotid ultrasound: an iterative scale-space and spatial transformation approach.Medical & biological engineering & computing · 2017Article
- The educational gradient in cardiovascular risk factors: impact of shared family factors in 228,346 Norwegian siblings.BMC public health · 2017Article
- Growth of Carotid Intima-Media Thickness in Black and White Young Adults.Journal of the American Heart Association · 2016Article
- A review of ultrasound common carotid artery image and video segmentation techniques.Medical & biological engineering & computing · 2014Article
- Article
- Body mass index and height from infancy to adulthood and carotid intima-media thickness at 60 to 64 years in the 1946 British Birth Cohort Study.Arteriosclerosis, thrombosis, and vascular biology · 2014Article
- Adverse childhood experiences and the cardiovascular health of children: a cross-sectional study.BMC pediatrics · 2013Article
- IQ in childhood and atherosclerosis in middle-age: 40 Year follow-up of the Newcastle Thousand Families Cohort Study.Atherosclerosis · 2013Article
- Predictors of carotid intima-media thickness and carotid plaque in young Indian adults: the New Delhi birth cohort.International journal of cardiology · 2013Article
- Cardiovascular disease in childhood: the role of obesity.European journal of pediatrics · 2013Review
- Gender differences in the association between socioeconomic status and subclinical atherosclerosis.PloS one · 2013Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo quantify the direct and indirect effects of fetal life, childhood, and adult life on risk of cardiovascular disease at age 49-51 years.
designFollow up study of the "Newcastle thousand families" birth cohort established in 1947.
participants154 men and 193 women who completed a health and lifestyle questionnaire and attended for clinical examination between October 1996 and December 1998.
main outcome measuresCorrelations between mean intima-media thickness of the carotid artery (carotid intima-media thickness) and family history, birth weight, and socioeconomic position around birth; socioeconomic position, growth, illness, and adverse life events in childhood; and adult socioeconomic position, lifestyle, and biological risk markers. Proportions of variance in carotid intima-media thickness that were accounted for by each stage of the lifecourse.
resultsSocioeconomic position at birth and birth weight were negatively associated with carotid intima-media thickness, although only social class at birth in women was a statistically significant covariate independent of adult lifestyle. These early life variables accounted directly for 2.2% of total variance in men and 2.0% in women. More variation in carotid intima-media thickness was explained by adult socioeconomic position and lifestyle, which accounted directly and indirectly for 3.4% of variance in men (95% confidence interval 0.5% to 6.2%) and 7.6% in women (2.1% to 13.0%). Biological risk markers measured in adulthood independently accounted for a further 9.5% of variance in men (2.4% to 14.2%) and 4.9% in women (1.6% to 7.4%).
conclusionsAdult lifestyle and biological risk markers were the most important determinants of the cardiovascular health of the study members of the Newcastle thousand families cohort at age 49-51 years. The limited overall effect of early life factors may reflect the postwar birth year of this cohort.
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Registered trials
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