ReviewJournal of immunological methods1999
Transgenic milk as a method for the production of recombinant antibodies.
Review in Journal of immunological methods, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed.
- Safety and real-world effectiveness of eptacog beta with emicizumab prophylaxis: an interim analysis of the ATHN 16 study.Blood vessels, thrombosis & hemostasis · 2026Article
- The landscape of antibody production systems: recombinant expression for research, diagnostics and therapy.Frontiers in bioengineering and biotechnology · 2026Review
- Recombinant factor VIIa: new insights into the mechanism of action through product innovation.Research and practice in thrombosis and haemostasis · 2025Review
- Review
- Small Ruminants and Its Use in Regenerative Medicine: Recent Works and Future Perspectives.Biology · 2021Review
- Generation of goats by nuclear transfer: a retrospective analysis of a commercial operation (1998-2010).Transgenic research · 2020Article
- Generation of transgenic goats by pronuclear microinjection: a retrospective analysis of a commercial operation (1995-2012).Transgenic research · 2018Article
- The transgenic animal platform for biopharmaceutical production.Transgenic research · 2016Review
- Expression of Active Fluorophore Proteins in the Milk of Transgenic Pigs Bypassing the Secretory Pathway.Scientific reports · 2016Article
- Production of Human Albumin in Pigs Through CRISPR/Cas9-Mediated Knockin of Human cDNA into Swine Albumin Locus in the Zygotes.Scientific reports · 2015Article
- Characterization of anti-CD20 monoclonal antibody produced by transgenic silkworms (Bombyx mori).mAbs · 2015Article
- Investigation of hFVIII production in mammary glands of transgenic mice.Monoclonal antibodies in immunodiagnosis and immunotherapy · 2014Article
- Production of transgenic goats expressing human coagulation factor IX in the mammary glands after nuclear transfer using transfected fetal fibroblast cells.Transgenic research · 2013Article
- Use of transgenic animals in biotechnology: prospects and problems.Acta naturae · 2013Article
- Article
- The extremely high level expression of human serum albumin in the milk of transgenic mice.Transgenic research · 2012Article
- Degenerate primer design to clone the human repertoire of immunoglobulin heavy chain variable regions.World journal of microbiology & biotechnology · 2012Article
- The recombinant chimeric antibody chHAb18 against hepatocellular carcinoma can be produced in milk of transgenic mice.Transgenic research · 2011Article
- Production of recombinant albumin by a herd of cloned transgenic cattle.Transgenic research · 2009Article
- High level expression of a functional human/mouse chimeric anti-CD20 monoclonal antibody in milk of transgenic mice.Transgenic research · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recombinant antibodies and their derivatives are increasingly being used as therapeutic agents. Clinical applications of antibodies often require large amounts of highly purified molecules, sometimes for multiple treatments. The development of very efficient expression systems is essential to the full exploitation of the antibody technology. Production of recombinant protein in the milk of transgenic dairy animals is currently being tested as an alternative to plasma fractionation for the manufacture of a number of blood factors (human antithrombin, human alpha-1-antitrypsin, human serum albumin, factor IX). The ability to routinely yield mg/ml levels of antibodies and the scale-up flexibility make transgenic production an attractive alternative to mammalian cell culture as a source of large quantities of biotherapeutics. The following review examines the potential of transgenic expression for the production of recombinant therapeutic antibodies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.