ArticleMolecular and cellular biology2000
Minimal phenotype of mice homozygous for a null mutation in the forkhead/winged helix gene, Mf2.
Article in Molecular and cellular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 58 citations in OpenAlex.
- Bridging structure and function: artificial intelligence-based modelling of kidney proteins.Nature reviews. Nephrology · 2026Review
- Implication of transcription factor FOXD2 dysfunction in syndromic congenital anomalies of the kidney and urinary tract (CAKUT).Kidney international · 2024Article
- The membrane-associated ubiquitin ligase MARCHF8 stabilizes the human papillomavirus oncoprotein E7 by degrading CUL1 and UBE2L3 in head and neck cancer.Journal of virology · 2024Article
- The membrane-associated ubiquitin ligase MARCHF8 stabilizes the human papillomavirus oncoprotein E7 by degrading CUL1 and UBE2L3 in head and neck cancer.bioRxiv : the preprint server for biology · 2023Article
- The genetics and pathogenesis of CAKUT.Nature reviews. Nephrology · 2023Review
- Forkhead box protein D2 suppresses colorectal cancer by reprogramming enhancer interactions.Nucleic acids research · 2023Article
- Understanding the Complex Milieu of Epithelial-Mesenchymal Transition in Cancer Metastasis: New Insight Into the Roles of Transcription Factors.Frontiers in oncology · 2021Review
- Differentiating Induced Pluripotent Stem Cells into Renal Cells: A New Approach to Treat Kidney Diseases.Stem cells international · 2020Review
- EMT Factors and Metabolic Pathways in Cancer.Frontiers in oncology · 2020Review
- Global polysome analysis of normal and injured podocytes.American journal of physiology. Renal physiology · 2019Article
- Regulation of the adrenocortical stem cell niche: implications for disease.Nature reviews. Endocrinology · 2015Review
- Sonic Hedgehog Signaling and VACTERL Association.Molecular syndromology · 2013Article
- Generation of conditional alleles for Foxc1 and Foxc2 in mice.Genesis (New York, N.Y. : 2000) · 2012Article
- Molecular and genetic basis of inherited nephrotic syndrome.International journal of nephrology · 2011Article
- Differences in aggressive behavior and DNA copy number variants between BALB/cJ and BALB/cByJ substrains.Behavior genetics · 2010Article
- Localization of a gene for nonsyndromic renal hypodysplasia to chromosome 1p32-33.American journal of human genetics · 2007Article
- Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia.Genes & development · 2004Article
- Dynamic (re)organization of the podocyte actin cytoskeleton in the nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2004Review
- Essential structural and functional determinants within the forkhead domain of FOXC1.Nucleic acids research · 2004Article
- The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis.Genes & development · 2001Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mf2 (mesoderm/mesenchyme forkhead 2) encodes a forkhead/winged helix transcription factor expressed in numerous tissues of the mouse embryo, including paraxial mesoderm, somites, branchial arches, vibrissae, developing central nervous system, and developing kidney. We have generated mice homozygous for a null mutation in the Mf2 gene (Mf2(lacZ)) to examine its role during embryonic development. The lacZ allele also allows monitoring of Mf2 gene expression. Homozygous null mutants are viable and fertile and have no major developmental defects. Some mutants show renal abnormalities, including kidney hypoplasia and hydroureter, but the penetrance of this phenotype is only 40% or lower, depending on the genetic background. These data suggest that Mf2 can play a unique role in kidney development, but there is functional redundancy in this organ and other tissues with other forkhead/winged helix genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.