ArticleMolecular and cellular biology2000
Identification of a novel element required for processing of intron-encoded box C/D small nucleolar RNAs in Saccharomyces cerevisiae.
Article in Molecular and cellular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Maturation of small nucleolar RNAs: from production to function.RNA biology · 2023Review
- Splicing inactivation generates hybrid mRNA-snoRNA transcripts targeted by cytoplasmic RNA decay.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Small nucleolar RNAs functioning and potential roles in cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Review
- Alternative spliceosome assembly pathways revealed by single-molecule fluorescence microscopy.Cell reports · 2013Article
- Experimental identification and analysis of macronuclear non-coding RNAs from the ciliate Tetrahymena thermophila.Nucleic acids research · 2012Article
- Accumulation of noncoding RNA due to an RNase P defect in Saccharomyces cerevisiae.RNA (New York, N.Y.) · 2011Article
- Processing of a dicistronic tRNA-snoRNA precursor: combined analysis in vitro and in vivo reveals alternate pathways and coupling to assembly of snoRNP.Plant physiology · 2009Article
- Genome-wide search for yeast RNase P substrates reveals role in maturation of intron-encoded box C/D small nucleolar RNAs.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- The position of yeast snoRNA-coding regions within host introns is essential for their biosynthesis and for efficient splicing of the host pre-mRNA.RNA (New York, N.Y.) · 2007Article
- The PMC2NT domain of the catalytic exosome subunit Rrp6p provides the interface for binding with its cofactor Rrp47p, a nucleic acid-binding protein.Nucleic acids research · 2007Article
- Cotranscriptional recognition of human intronic box H/ACA snoRNAs occurs in a splicing-independent manner.Molecular and cellular biology · 2006Article
- Coupling between snoRNP assembly and 3' processing controls box C/D snoRNA biosynthesis in yeast.The EMBO journal · 2004Article
- A structural, phylogenetic, and functional study of 15.5-kD/Snu13 protein binding on U3 small nucleolar RNA.RNA (New York, N.Y.) · 2003Article
- Naf1p, an essential nucleoplasmic factor specifically required for accumulation of box H/ACA small nucleolar RNPs.Molecular and cellular biology · 2002Article
- Mammalian and yeast U3 snoRNPs are matured in specific and related nuclear compartments.The EMBO journal · 2002Article
- Functional analysis of yeast snoRNA and snRNA 3'-end formation mediated by uncoupling of cleavage and polyadenylation.Molecular and cellular biology · 2002Article
- Small nucleolar RNAs: versatile trans-acting molecules of ancient evolutionary origin.Gene expression · 2002Review
- Release of U18 snoRNA from its host intron requires interaction of Nop1p with the Rnt1p endonuclease.The EMBO journal · 2001Article
- Yeast snoRNA accumulation relies on a cleavage-dependent/polyadenylation-independent 3'-processing apparatus.The EMBO journal · 2000Article
- Processing of intron-encoded box C/D small nucleolar RNAs lacking a 5',3'-terminal stem structure.Molecular and cellular biology · 2000Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Processing of intron-encoded box C/D small nucleolar RNAs (snoRNAs) in metazoans through both the splicing-dependent and -independent pathways requires the conserved core motif formed by boxes C and D and the adjoining 5'-3'-terminal stem. By comparative analysis, we found that five out of six intron-encoded box C/D snoRNAs in yeast do not possess a canonical terminal stem. Instead, complementary regions within the flanking host intron sequences have been identified in all these cases. Here we show that these sequences are essential for processing of U18 and snR38 snoRNAs and that they compensate for the lack of a canonical terminal stem. We also show that the Rnt1p endonuclease, previously shown to be required for the processing of many snoRNAs encoded by monocistronic or polycistronic transcriptional units, is not required for U18 processing. Our results suggest a role of the complementary sequences in the early recognition of intronic snoRNA substrates and point out the importance of base pairing in favoring the communication between boxes C and D at the level of pre-snoRNA molecules for efficient assembly with snoRNP-specific factors.
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