ArticleThe Journal of cell biology2000
Cytokine-induced nuclear factor kappa B activation promotes the survival of developing neurons.
Article in The Journal of cell biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed, 147 citations in OpenAlex.
- Review
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- Comprehensive Mapping of the Cell Response toFrontiers in microbiology · 2021Article
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- Preventive Effect of Cardiotrophin-1 Administration before DSS-Induced Ulcerative Colitis in Mice.Journal of clinical medicine · 2019Article
- Inhibition of NMDA Receptors Prevents the Loss of BDNF Function Induced by Amyloid β.Frontiers in pharmacology · 2018Article
- The Role of BDNF in Peripheral Nerve Regeneration: Activity-Dependent Treatments and Val66Met.Frontiers in cellular neuroscience · 2018Review
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- Transcriptional Regulation of Human Transforming Growth Factor-α in Astrocytes.Molecular neurobiology · 2017Article
- Natural allelic variation of the IL-21 receptor modulates ischemic stroke infarct volume.The Journal of clinical investigation · 2016Article
- The p75 neurotrophin receptor augments survival signaling in the striatum of pre-symptomatic Q175(WT/HD) mice.Neuroscience · 2016Article
- NF-KappaB in Long-Term Memory and Structural Plasticity in the Adult Mammalian Brain.Frontiers in molecular neuroscience · 2015Review
- Pro-/anti-inflammatory dysregulation in patients with first episode of psychosis: toward an integrative inflammatory hypothesis of schizophrenia.Schizophrenia bulletin · 2014Article
- Spinal muscular atrophy: new findings for an old pathology.Brain pathology (Zurich, Switzerland) · 2013Review
- Ciliary neurotrophic factor activates NF-κB to enhance mitochondrial bioenergetics and prevent neuropathy in sensory neurons of streptozotocin-induced diabetic rodents.Neuropharmacology · 2013Article
- Inflammatory cytokines promote mesenchymal transformation in embryonic and adult valve endothelial cells.Arteriosclerosis, thrombosis, and vascular biology · 2013Article
- Inhibition of NF-κB signaling commits resveratrol-treated medulloblastoma cells to apoptosis without neuronal differentiation.Journal of neuro-oncology · 2011Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), cardiotrophin-1 (CT-1), and interleukin 6 (IL-6) comprise a group of structurally related cytokines that promote the survival of subsets of neurons in the developing peripheral nervous system, but the signaling pathways activated by these cytokines that prevent neuronal apoptosis are unclear. Here, we show that these cytokines activate NF-kappaB in cytokine-dependent developing sensory neurons. Preventing NF-kappaB activation with a super-repressor IkappaB-alpha protein markedly reduces the number of neurons that survive in the presence of cytokines, but has no effect on the survival response of the same neurons to brain-derived neurotrophic factors (BDNF), an unrelated neurotrophic factor that binds to a different class of receptors. Cytokine-dependent sensory neurons cultured from embryos that lack p65, a transcriptionally active subunit of NF-kappaB, have a markedly impaired ability to survive in response to cytokines, but respond normally to BDNF. There is increased apoptosis of cytokine- dependent neurons in p65(-/)- embryos in vivo, resulting in a reduction in the total number of these neurons compared with their numbers in wild-type embryos. These results demonstrate that NF-kappaB plays a key role in mediating the survival response of developing neurons to cytokines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.