ArticleDrug safety2000
Assessment of infant development during an 18-month follow-up after treatment of infections in pregnant women with cefuroxime axetil.
Article in Drug safety, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Article
- Diagnosis and treatment of allergic rhinitis and sinusitis during pregnancy and lactation.Clinical reviews in allergy & immunology · 2004Review
- Antibacterial use in pregnancy.Drug safety · 2000Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChoices of antibacterial for infections in pregnancy are limited because of potential risks to the fetus, particularly in the early months. However, infections may result in preterm labour or other problems and so treatment is needed. Increasingly, resistance is reported among common pathogens to older agents, such as ampicillin or amoxicillin, that have been widely used in pregnancy.
objectiveTo assess the safety and efficacy of cefuroxime axetil in the treatment of infections during pregnancy.
designThis was a retrospective analysis of case records for women who were treated with cefuroxime axetil at some point during pregnancy.
settingPatients were treated at one centre in Lubliniec, Poland in 1996 and 1997. PATIENTS AND
participantsThe study included 78 women aged 19 to 38 years (mean 26 years) and their 80 infants. MAIN OUTCOME MEASURES AND
resultsEfficacy in treating maternal infections was assessed, and the physical and mental development of children born to treated mothers was evaluated for at least 18 months after birth. 13 women were treated in the first trimester, 19 in the second trimester and 46 in the third trimester. There were no abnormalities causing concern in terms of physical or mental development in any of the children, and no abnormality that was attributable to the treatment the mother had received.
conclusionsThe results add clinical support for the use of cefuroxime axetil in pregnancy if an antibacterial is needed, thus offering an alternative if antibacterial resistance to older agents is an issue for the pregnant mother.
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Identifiers
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Registered trials
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