ArticleBritish journal of cancer2000
Screen-detected breast cancers have a lower mitotic activity index.
Article in British journal of cancer, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 39 citations in OpenAlex.
- Defining the area of mitoses counting in invasive breast cancer using whole slide image.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022Article
- Poor Biological Factors and Prognosis of Interval Breast Cancers: Long-Term Results of Bahçeşehir (Istanbul) Breast Cancer Screening Project in Turkey.JCO global oncology · 2020Article
- Comparison of patients with small (≤2 cm) breast cancer according to adherence to breast screening program.PloS one · 2017Article
- Lower mitotic activity in BRCA1/2-associated primary breast cancers occurring after risk-reducing salpingo-oophorectomy.Cancer biology & therapy · 2014Article
- Copy number imbalances between screen- and symptom-detected breast cancers and impact on disease-free survival.Cancer prevention research (Philadelphia, Pa.) · 2011Article
- Long-term prognosis of breast cancer detected by mammography screening or other methods.Breast cancer research : BCR · 2011Article
- Predictive value of tumor proliferative indices in periampullary cancers: Ki-67, mitotic activity index (MI) and volume corrected mitotic index (M/V) using tissue microarrays.World journal of surgery · 2010Article
- Screening for breast cancer.JAMA · 2005Review
- Screen-detected vs clinical breast cancer: the advantage in the relative risk of lymph node metastases decreases with increasing tumour size.British journal of cancer · 2005Article
- Prognostic value of proliferation in invasive breast cancer: a review.Journal of clinical pathology · 2004Review
- Preoperative selection of symptomatic breast cancer patients appropriate for lymphatic mapping and sentinel node biopsy.Irish journal of medical scienceArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We know that screening for breast cancer leads to detection of smaller tumours with less lymph node metastases. Could it be possible that the decrease in mortality after screening is not only caused by this earlier stage, but also by a different mitotic activity index (MAI) of the tumours that are detected by screening? Is MAI a prognostic factor for recurrence-free survival? A retrospective study was carried out of 387 patients with breast cancer, treated at the University Hospital Nijmegen between January 1992 and September 1997. Ninety patients had screen-detected breast cancer, 297 patients had breast cancers detected outside the screening programme. The MAI, other prognostic factors and recurrence-free survival were determined. In non-screen-detected tumours the MAI is twice as high as in screen-detected tumours, even after correction for age took place. The MAI correlated well with other tumour characteristics. The MAI in itself is a prognostic factor for recurrence-free survival. Favourable outcome in screen detected breast cancer is not entirely caused by detecting cancer in early stages: quantitative features such as the MAI indicate a less malignant character of screen detected breast cancer. The MAI is an independent prognostic factor for recurrence-free survival.
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