ArticleBritish journal of cancer2000
Vascular grading of angiogenesis: prognostic significance in breast cancer.
Article in British journal of cancer, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Survival estimates stratified by the Nottingham Prognostic Index for early breast cancer: a systematic review and meta-analysis of observational studies.Systematic reviews · 2018Pooled it
- Exploring the tumor microenvironment of breast cancer to develop a prognostic model and predict immunotherapy responses.Scientific reports · 2025Article
- Quantifying the tumour vasculature environment from CD-31 immunohistochemistry images of breast cancer using deep learning based semantic segmentation.Breast cancer research : BCR · 2025Article
- Current trends in the characterization and monitoring of vascular response to cancer therapy.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024Review
- Functional Ultrasound (fUS) During Awake Brain Surgery: The Clinical Potential of Intra-Operative Functional and Vascular Brain Mapping.Frontiers in neuroscience · 2019Article
- RNAi-mediated inhibition of Lgr5 leads to decreased angiogenesis in gastric cancer.Oncotarget · 2017Article
- Article
- Y-box binding protein 1 expression in gastric cancer subtypes and association with cancer neovasculature.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2015Article
- Article
- Aberrant expression of EphA3 in gastric carcinoma: correlation with tumor angiogenesis and survival.Journal of gastroenterology · 2012Article
- Computerized three-class classification of MRI-based prognostic markers for breast cancer.Physics in medicine and biology · 2011Article
- Article
- Immunostaining with D2-40 improves evaluation of lymphovascular invasion, but may not predict sentinel lymph node status in early breast cancer.BMC cancer · 2009Article
- The relationship between the systemic inflammatory response, tumour proliferative activity, T-lymphocytic and macrophage infiltration, microvessel density and survival in patients with primary operable breast cancer.British journal of cancer · 2008Article
- The determination of VEGF and MVD, among patients with primary breast cancer.Pathology oncology research : POR · 2008Article
- Feasibility of near-infrared diffuse optical spectroscopy on patients undergoing imageguided core-needle biopsy.Optics express · 2007Article
- Independent prognostic value of angiogenesis and the level of plasminogen activator inhibitor type 1 in breast cancer patients.British journal of cancer · 2003Article
- Expression of CD34 in gastric cancer and its correlation with histology, stage, proliferation activity, p53 expression and apoptotic index.Pathology oncology research : POR · 2001Article
- What modifies the relation between tumour size and lymph node metastases in T1 breast carcinomas?Journal of clinical pathology · 2000Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The study aimed to evaluate the prognostic value of angiogenesis by vascular grading of primary breast tumours, and to evaluate the prognostic impact of adding the vascular grade to the Nottingham Prognostic Index (NPI). The investigation included 836 patients. The median follow-up time was 11 years and 4 months. The microvessels were immunohistochemically stained by antibodies against CD34. Angiogenesis was graded semiquantitatively by subjective scoring into three groups according to the expected number of microvessels in the most vascular tumour area. The vascular grading between observers was moderately reproduced (kappa = 0.59). Vascular grade was significantly associated with axillary node involvement, tumour size, malignancy grade, oestrogen receptor status and histological type. In univariate analyses vascular grade significantly predicted recurrence free survival and overall survival for all patients (P < 0.0001), node-negative patients (P < 0.0001) and node-positive patients (P < 0.0001). Cox multivariate regression analysis showed that vascular grading contributed with independent prognostic value in all patients (P < 0.0001). A prognostic index including the vascular grade had clinical impact for 24% of the patients, who had a shift in prognostic group, as compared to NPI, and implied a better prognostic dissemination. We concluded that the angiogenesis determined by vascular grading has independent prognostic value of clinical relevance for patients with breast cancer.
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