ArticleBritish journal of cancer2000
Association of specific chromosome alterations with tumour phenotype in posterior uveal melanoma.
Article in British journal of cancer, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 81 citations in OpenAlex.
- Identification of two distinct uveal melanoma subtypes based on the immune cell infiltration of the primary tumour.Cancer immunology, immunotherapy : CII · 2025Article
- Clinical Value of MLPA for Prognostic Assessment of Chromosomal Rearrangements and DNA Methylation in Uveal Melanoma.Investigative ophthalmology & visual science · 2025Article
- Article
- New Treatment Horizons in Uveal and Cutaneous Melanoma.Life (Basel, Switzerland) · 2023Review
- Genetics and RNA Regulation of Uveal Melanoma.Cancers · 2023Review
- Scientific and clinical implications of genetic and cellular heterogeneity in uveal melanoma.Molecular biomedicine · 2021Review
- Increased Non-Homologous End Joining Makes DNA-PK a Promising Target for Therapeutic Intervention in Uveal Melanoma.Cancers · 2019Article
- Characterization of luteinizing hormone-releasing hormone receptor type I (LH-RH-I) as a potential molecular target in OCM-1 and OCM-3 human uveal melanoma cell lines.OncoTargets and therapy · 2018Article
- ICG-001 Exerts Potent Anticancer Activity Against Uveal Melanoma Cells.Investigative ophthalmology & visual science · 2018Article
- Association of tumor and plasma microRNA expression with tumor monosomy-3 in patients with uveal melanoma.Clinical epigenetics · 2016Article
- Heterogeneity revealed by integrated genomic analysis uncovers a molecular switch in malignant uveal melanoma.Oncotarget · 2015Article
- Melanoma epidemiology, biology and prognosis.EJC supplements : EJC : official journal of EORTC, European Organization for Research and Treatment of Cancer ... [et al.] · 2013Review
- Chromosome 3 status in uveal melanoma: a comparison of fluorescence in situ hybridization and single-nucleotide polymorphism array.Investigative ophthalmology & visual science · 2012Article
- Genetics of uveal melanoma and cutaneous melanoma: two of a kind?Dermatology research and practice · 2010Article
- The biology and management of uveal melanoma.Current oncology reports · 2008Review
- Chromosome 3 analysis of uveal melanoma using fine-needle aspiration biopsy at the time of plaque radiotherapy in 140 consecutive cases.Transactions of the American Ophthalmological Society · 2007Article
- An alternative hypothesis for observed mortality rates due to metastasis after treatment of choroidal melanomas of different sizes.Transactions of the American Ophthalmological Society · 2007Review
- The identification of chromosome abnormalities associated with the invasive phenotype of uveal melanoma in vitro.Clinical & experimental metastasis · 2005Article
- Identification of monosomy 3 in choroidal melanoma by chromosome in situ hybridisation.The British journal of ophthalmology · 2004Article
- Absence of BRAF gene mutations in uveal melanomas in contrast to cutaneous melanomas.British journal of cancer · 2003Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Posterior uveal melanomas have recurrent alterations of chromosomes 1, 3, 6 and 8. In particular, changes of chromosomes 3 and 8 occur in association, appear to characterize those tumours with a ciliary body component, and have been shown to be of prognostic significance. The relevance of other chromosome alterations is less certain. We have performed cytogenetic analysis on 42 previously untreated primary posterior uveal melanomas. Of interest was the observation that as tumour size increased the involvement of specific chromosome changes, and the amount of chromosome abnormalities likewise increased. Loss, or partial deletions, of the short arm of chromosome 1 were found to associate with larger ciliary body melanomas; typically, loss of the short arm resulted from unbalanced translocations, the partners of which varied. Trisomy of chromosome 21 occurred more often in ciliary body melanomas, whilst rearrangements of chromosomes 6 and 11 were primarily related to choroidal melanomas. Our results imply that alterations of chromosome 1 are important in the progression of some uveal melanomas, and that other chromosome abnormalities, besides those of chromosomes 3 and 8, are associated with ocular tumours of particular locations.
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Registered trials
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