ArticleOncogene2000
Regulation of B-Myb activity by cyclin D1.
Article in Oncogene, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 60 citations in OpenAlex.
- Cathepsin L induced PC-12 cell apoptosis via activation of B-Myb and regulation of cell cycle proteins.Acta pharmacologica Sinica · 2019Article
- Cyclin D1 overexpression induces global transcriptional downregulation in lymphoid neoplasms.The Journal of clinical investigation · 2018Article
- (-)-Gochnatiolide B, synthesized from dehydrocostuslactone, exhibits potent anti-bladder cancer activity in vitro and in vivo.Scientific reports · 2018Article
- Tumor suppression by the EGR1, DMP1, ARF, p53, and PTEN Network.Cancer investigation · 2018Article
- Hormone-induced DNA damage response and repair mediated by cyclin D1 in breast and prostate cancer.Oncotarget · 2017Review
- MYBL2 (B-Myb): a central regulator of cell proliferation, cell survival and differentiation involved in tumorigenesis.Cell death & disease · 2017Review
- Interplay with the Mre11-Rad50-Nbs1 complex and phosphorylation by GSK3β implicate human B-Myb in DNA-damage signaling.Scientific reports · 2017Article
- Novel Molecular Markers for Breast Cancer.Biomarkers in cancer · 2016Review
- Aberrant expression of cyclin D1 in cancer.Signal transduction insights · 2015Article
- B-myb is a gene implicated in cell cycle and proliferation of breast cancer.International journal of clinical and experimental pathology · 2014Article
- Cooperation between Dmp1 loss and cyclin D1 overexpression in breast cancer.The American journal of pathology · 2013Article
- B-Myb switches from Cyclin/Cdk-dependent to Jnk- and p38 kinase-dependent phosphorylation and associates with SC35 bodies after UV stress.Cell death & disease · 2013Article
- B-Myb promotes S-phase independently of its sequence-specific DNA binding activity and interacts with polymerase delta-interacting protein 1 (Pdip1).Cell cycle (Georgetown, Tex.) · 2012Article
- Article
- The role of oncogenes in gastrointestinal cancer.Gastrointestinal cancer research : GCR · 2010Article
- Explorative data analysis of MCL reveals gene expression networks implicated in survival and prognosis supported by explorative CGH analysis.BMC cancer · 2008Article
- Signal transduction involving the dmp1 transcription factor and its alteration in human cancer.Clinical medicine. Oncology · 2008Article
- Dmp1 and tumor suppression.Oncogene · 2007Review
- Evidence for CDK-dependent and CDK-independent functions of the murine gammaherpesvirus 68 v-cyclin.Journal of virology · 2006Article
- The cyclin D1b splice variant: an old oncogene learns new tricks.Cell division · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence obtained during recent years suggests that B-Myb, a highly conserved member of the Myb transcription factor family, plays a key role in cell proliferation. We have shown previously that the activity of B-Myb is stimulated by cyclin A/Cdk2-dependent phosphorylation of the carboxyl-terminus of B-Myb. We have now investigated in more detail the effect of other cyclins on B-Myb. Here, we show that cyclin D1, in contrast to cyclin A, strongly inhibits the activity of B-Myb. This inhibitory effect does not involve increased phosphorylation of B-Myb but seems to rely on the formation of a specific complex of B-Myb and cyclin D1. Our work identifies B-Myb as an interacting partner for cyclin D1 and suggest that the activity of B-Myb during the cell cycle is controlled by the antagonistic effects of cyclin D1 and A. The results presented here suggest a more general role of cyclin D1 as regulator of transcription in addition to the known effect on RB phosphorylation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.