ArticleOncogene2000
AP-2 transcription factors in the regulation of ERBB2 gene transcription by oestrogen.
Article in Oncogene, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 58 citations in OpenAlex.
- DSCAM-AS1-Driven Proliferation of Breast Cancer Cells Involves Regulation of Alternative Exon Splicing and 3'-End Usage.Cancers · 2020Article
- Contribution of synergism between PHF8 and HER2 signalling to breast cancer development and drug resistance.EBioMedicine · 2020Article
- Membrane-bound estrogen receptor alpha initiated signaling is dynamin dependent in breast cancer cells.European journal of medical research · 2018Article
- Article
- The role of BST-2/Tetherin in host protection and disease manifestation.Immunity, inflammation and disease · 2016Review
- Estrogen represses gene expression through reconfiguring chromatin structures.Nucleic acids research · 2013Article
- Article
- Superoxide dismutase 3 is induced by antioxidants, inhibits oxidative DNA damage and is associated with inhibition of estrogen-induced breast cancer.Carcinogenesis · 2012Article
- Cross-regulation between FOXA1 and ErbB2 signaling in estrogen receptor-negative breast cancer.Neoplasia (New York, N.Y.) · 2012Article
- AP-2γ regulates oestrogen receptor-mediated long-range chromatin interaction and gene transcription.The EMBO journal · 2011Article
- Breaking the cycle: An insight into the role of ERα in eukaryotic cell cycles.Journal of carcinogenesis · 2011Article
- Aspirin inhibits ErbB2 to induce apoptosis in cervical cancer cells.Medical oncology (Northwood, London, England) · 2010Article
- Estrogen receptor alpha controls a gene network in luminal-like breast cancer cells comprising multiple transcription factors and microRNAs.The American journal of pathology · 2010Article
- Histone deacetylase 7 and FoxA1 in estrogen-mediated repression of RPRM.Molecular and cellular biology · 2010Article
- Induction of ErbB2 by ultraviolet A irradiation: potential role in malignant transformation of keratinocytes.Cancer science · 2008Article
- Genistein affects HER2 protein concentration, activation, and promoter regulation in BT-474 human breast cancer cells.Endocrine · 2007Article
- Activator protein-2gamma (AP-2gamma) expression is specifically induced by oestrogens through binding of the oestrogen receptor to a canonical element within the 5'-untranslated region.The Biochemical journal · 2004Article
- Article
- Effects of in vivo heregulin beta1 treatment in wild-type and ErbB gene-targeted mice depend on receptor levels and pregnancy.The American journal of pathology · 2001Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcription of the ERBB2 oncogene is repressed by oestrogen in human breast cancer cells. We show that a 218 bp fragment of the human ERBB2 gene promoter is responsive to oestrogen in transient transfection in ZR75.1 and SKBR.3 cells when the oestrogen receptor is expressed. Deletion analysis of this fragment shows that a sequence located at the 5' end, which is known to mediate ERBB2 overexpression in breast cancer, is also responsible for the oestrogen response. This sequence binds AP-2 transcription factors and appears functionally identical to an element of the oestrogen-dependent enhancer described in the first intron of human ERBB2. We observed that oestrogen treatment down-regulates expression of AP-2 proteins but does not affect the DNA binding activity of AP-2. Constitutive expression of AP-2beta or AP-2gamma, but not AP-2alpha, abrogates the estrogenic repression. Our results demonstrate that AP-2 transcription factors are implicated in the oestrogenic regulation of ERBB2 gene expression and suggest a complex interplay involving the different AP-2 isoforms and other unidentified factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.