ArticleOncogene2000
Inhibitory interaction of c-Myb and GATA-1 via transcriptional co-activator CBP.
Article in Oncogene, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed.
- Tumor Cell-Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model.Cancer immunology research · 2023Article
- MYB oncoproteins: emerging players and potential therapeutic targets in human cancer.Oncogenesis · 2021Review
- Identification of a Siglec-F+ granulocyte-macrophage progenitor.Journal of leukocyte biology · 2018Article
- c-Myb regulates matrix metalloproteinases 1/9, and cathepsin D: implications for matrix-dependent breast cancer cell invasion and metastasis.Molecular cancer · 2012Article
- Egr-1 transactivates Bim gene expression to promote neuronal apoptosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- p73 plays a role in erythroid differentiation through GATA1 induction.The Journal of biological chemistry · 2009Article
- Cell type specificity of a diffusible inducer is determined by a GATA family transcription factor.Development (Cambridge, England) · 2008Article
- The human T-cell leukemia virus type 1 tax protein confers CBP/p300 recruitment and transcriptional activation properties to phosphorylated CREB.Molecular and cellular biology · 2008Article
- GATA-2 functions downstream of BMPs and CaM KIV in ectodermal cells during primitive hematopoiesis.Developmental biology · 2007Article
- The carbonic anhydrase I locus contains a c-Myb target promoter and modulates differentiation of murine erythroleukemia cells.Oncogene · 2006Article
- GATA1-mediated megakaryocyte differentiation and growth control can be uncoupled and mapped to different domains in GATA1.Molecular and cellular biology · 2005Article
- Regulation of FeLV-945 by c-Myb binding and CBP recruitment to the LTR.Virology journal · 2004Article
- Article
- Mutual repression of transcriptional activation between the ETS-related factor ERG and estrogen receptor.Oncogene · 2003Article
- Modulation of retinoid signaling by a cytoplasmic viral protein via sequestration of Sp110b, a potent transcriptional corepressor of retinoic acid receptor, from the nucleus.Molecular and cellular biology · 2003Article
- Progression through key stages of haemopoiesis is dependent on distinct threshold levels of c-Myb.The EMBO journal · 2003Article
- GATA-2 and GATA-2/ER display opposing activities in the development and differentiation of blood progenitors.The EMBO journal · 2002Article
- Inhibition of CBP-mediated protein acetylation by the Ets family oncoprotein PU.1.Molecular and cellular biology · 2002Article
- Molecular control of megakaryopoiesis and thrombopoiesis.International journal of hematology · 2002Review
- Regulation of hematopoietic stem cell fate.Oncogene · 2002Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene targeting experiments have revealed that transcription factors such as c-Myb and GATA-1 play crucial roles during hematopoietic differentiation. c-Myb is necessary in the immature cells of almost every hematopoietic lineage and GATA-1 is essential for the development of the erythroid lineage. In addition, CREB-binding protein (CBP) acts as a transcriptional adapter for various transcription factors, including c-Myb and GATA-1. In this paper, we show that the transcription factors c-Myb and GATA-1 each inhibit the transcriptional activity of the other and that any possible bipartite complexes c-Myb, GATA-1, and CBP could be formed, but the tripartite complex was hardly formed. The exclusive binding of GATA-1 and c-Myb to CBP is probably the molecular basis for the mutual inhibition of their transcriptional activity. Our data suggest that cross-talk between these three factors might be important for hematopoietic differentiation and that CBP functions as a key molecule during the process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.