ArticleJournal of virology2000
Multiple integrations of human foamy virus in persistently infected human erythroleukemia cells.
Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- Inhibition of spumavirus gene expression by PHF11.PLoS pathogens · 2020Article
- Foamy retrovirus integrase contains a Pol dimerization domain required for protease activation.Journal of virology · 2011Article
- A nuclear export signal within the structural Gag protein is required for prototype foamy virus replication.Retrovirology · 2011Article
- Nonintegrating foamy virus vectors.Journal of virology · 2010Article
- Viruses and thyroiditis: an update.Virology journal · 2009Review
- Role of the foamy virus Pol cleavage site in viral replication.Journal of virology · 2007Article
- Identification and characterization of an exogenous retrovirus from atlantic salmon swim bladder sarcomas.Journal of virology · 2006Article
- A novel function for spumaretrovirus integrase: an early requirement for integrase-mediated cleavage of 2 LTR circles.Retrovirology · 2005Article
- Persistent infection with primate foamy virus type 1 increases human immunodeficiency virus type 1 cell binding via a Bet-independent mechanism.Journal of virology · 2004Article
- Role of the C terminus of foamy virus Gag in RNA packaging and Pol expression.Journal of virology · 2004Article
- Foamy virus integration.Journal of virology · 2004Article
- Retrotransposition and cell-to-cell transfer of foamy viruses.Journal of virology · 2003Article
- The promyelocytic leukemia protein does not mediate foamy virus latency in vitro.Journal of virology · 2003Article
- Reactivation of a complex retrovirus is controlled by a molecular switch and is inhibited by a viral protein.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Further characterization of equine foamy virus reveals unusual features among the foamy viruses.Journal of virology · 2002Article
- Cell-type-specific regulation of the two foamy virus promoters.Journal of virology · 2001Article
- Human foamy virus capsid formation requires an interaction domain in the N terminus of Gag.Journal of virology · 2001Article
- Efficient intracellular retrotransposition of an exogenous primate retrovirus genome.The EMBO journal · 2000Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Foamy viruses are complex retroviruses whose replication strategy resembles that of conventional retroviruses. However, foamy virus replication also resembles that of hepadnaviruses in many respects. Because hepadnaviruses replicate in an integrase-independent manner, we were interested in investigating the characteristics of human foamy virus (HFV) integration. We have shown that HFV requires a functional integrase protein for infectivity. Our analyses have revealed that in single-cell clones derived from HFV-infected erythroleukemia-derived cells (H92), there were up to 20 proviral copies per host cell genome as determined by Southern blot and fluorescent in situ hybridization analysis. Use of specific probes has also shown that a majority of the proviruses contain the complete tas gene, which encodes the viral transactivator, and are not derived from Deltatas cDNAs, which have been shown to arise rapidly in infected cells. To demonstrate that the multiple proviral sequences are due to integration instead of recombination, we have sequenced the junctions between the proviral sequences and the host genome and found that the proviruses have authentic long terminal repeat ends and that each integration is at a different chromosomal site. A virus lacking the Gag nuclear localization signal accumulates fewer proviruses, suggesting that nuclear translocation is important for high proviral load. Since persistently infected H92 clones are not resistant to superinfection, the relative importance of an intracellular versus extracellular mechanism in proviral acquisition has yet to be determined.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.