ArticleGut2000
Generation of reactive oxygen species by the faecal matrix.
Article in Gut, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 61 citations in OpenAlex.
- Assessment of complementary feeding of Canadian infants: effects on microbiome & oxidative stress, a randomized controlled trial.BMC pediatrics · 2017Trial
- New Insights into Aspirin's Anticancer Activity: The Predominant Role of Its Iron-Chelating Antioxidant Metabolites.Antioxidants (Basel, Switzerland) · 2024Review
- Immuno-physiological effects of dietary reishi mushroom powder as a source of beta-glucan on Rohu, Labeo rohita challenged with Aeromonas veronii.Scientific reports · 2023Article
- Prebiotics and Community Composition Influence Gas Production of the Human Gut Microbiota.mBio · 2020Article
- Xenobiotics Formed during Food Processing: Their Relation with the Intestinal Microbiota and Colorectal Cancer.International journal of molecular sciences · 2019Review
- Changes in urinary metabolic profiles of colorectal cancer patients enrolled in a prospective cohort study (ColoCare).Metabolomics : Official journal of the Metabolomic Society · 2015Article
- Gut Microbiota and Colorectal Cancer.Gastrointestinal tumors · 2015Review
- The role of antioxidants and pro-oxidants in colon cancer.World journal of gastrointestinal oncology · 2014Review
- Understanding the antimicrobial mechanism of TiO₂-based nanocomposite films in a pathogenic bacterium.Scientific reports · 2014Article
- The role of gut microbiota in the pathogenesis of colorectal cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Review
- Human heme oxygenase-1 efficiently catabolizes heme in the absence of biliverdin reductase.Drug metabolism and disposition: the biological fate of chemicals · 2010Article
- Inositol hexaphosphate-induced enhancement of natural killer cell activity correlates with suppression of colon carcinogenesis in rats.World journal of gastroenterology · 2005Article
- Radical induction theory of ulcerative colitis.World journal of gastroenterology · 2005Review
- Upregulation of vascular endothelial growth factor by hydrogen peroxide in human colon cancer.World journal of gastroenterology · 2002Article
- "Driver-passenger" bacteria and their metabolites in the pathogenesis of colorectal cancer.Gut microbesReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundReactive oxygen species are implicated in the aetiology of a range of human diseases and there is increasing interest in their role in the development of cancer.
aimTo develop a suitable method for the detection of reactive oxygen species produced by the faecal matrix.
methodsA refined high performance liquid chromatography system for the detection of reactive oxygen species is described.
resultsThe method allows baseline separation of the products of hydroxyl radical attack on salicylic acid in the hypoxanthine/xanthine oxidase system, namely 2,5-dihydroxybenzoic acid, 2,3-dihydroxybenzoic acid, and catechol. The increased efficiency and precision of the method has allowed a detailed evaluation of the dynamics of reactive oxygen species generation in the faecal matrix. The data show that the faecal matrix is capable of generating reactive oxygen species in abundance. This ability cannot be attributed to the bacteria present, but rather to a soluble component within the matrix. As yet, the nature of this soluble factor is not entirely clear but is likely to be a reducing agent.
conclusionsThe soluble nature of the promoting factor renders it amenable to absorption, and circumstances may exist in which either it comes into contact with either free or chelated iron in the colonocyte, leading to direct attack on cellular DNA, or else it initiates lipid peroxidation processes whereby membrane polyunsaturated fatty acids are attacked by reactive oxygen species propagating chain reactions leading to the generation of promutagenic lesions such as etheno based DNA adducts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.