ArticleThe Journal of clinical investigation2000
Desmoglein-1-specific T lymphocytes from patients with endemic pemphigus foliaceus (fogo selvagem).
Article in The Journal of clinical investigation, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 88 citations in OpenAlex.
- CD4Current molecular medicine · 2025Article
- Translational implications of Th17-skewed inflammation due to genetic deficiency of a cadherin stress sensor.The Journal of clinical investigation · 2022Article
- From Insect Bites to a Skin Autoimmune Disease: A Conceivable Pathway to Endemic Pemphigus Foliaceus.Frontiers in immunology · 2022Review
- Common Denominators in the Immunobiology of IgG4 Autoimmune Diseases: What Do Glomerulonephritis, Pemphigus Vulgaris, Myasthenia Gravis, Thrombotic Thrombocytopenic Purpura and Autoimmune Encephalitis Have in Common?Frontiers in immunology · 2020Review
- Involvement of the IL23/Th17 Pathway in the Pathogenesis of Tunisian Pemphigus Foliaceus.Mediators of inflammation · 2018Article
- Eosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairment.JCI insight · 2016Article
- Differential gene expression levels might explain association of LAIR2 polymorphisms with pemphigus.Human genetics · 2016Article
- Update on fogo selvagem, an endemic form of pemphigus foliaceus.The Journal of dermatology · 2015Review
- Genome-wide gene expression profiling reveals unsuspected molecular alterations in pemphigus foliaceus.Immunology · 2014Article
- Desmoglein-1 regulates esophageal epithelial barrier function and immune responses in eosinophilic esophagitis.Mucosal immunology · 2014Article
- Endemic pemphigus over a century: Part II.North American journal of medical sciences · 2010Article
- Deletional tolerance mediated by extrathymic Aire-expressing cells.Science (New York, N.Y.) · 2008Article
- T cell control in autoimmune bullous skin disorders.The Journal of clinical investigation · 2006Review
- Tumour necrosis factor-alpha polymorphism as one of the complex inherited factors in pemphigus.Mediators of inflammation · 2003Article
- High levels of interleukin-1 in patients with endemic pemphigus foliaceus.Clinical and diagnostic laboratory immunology · 2003Article
- The role of intramolecular epitope spreading in the pathogenesis of endemic pemphigus foliaceus (fogo selvagem).The Journal of experimental medicine · 2003Article
- Epistasis between DSG1 and HLA class II genes in pemphigus foliaceus.Genes and immunity · 2002Article
- Localized Pemphigus Foliaceus: Diverse Presentations, Treatment, and Review of the Literature.Indian journal of dermatologyArticle
- The Use of Intralesional Steroids in a Case of Localized Pemphigus Foliaceus.Case reports in dermatologyReview
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
Fogo selvagem (FS), the endemic form of pemphigus foliaceus, is a cutaneous autoimmune disease characterized by subcorneal blistering of the epidermis and the production of autoantibodies against the desmosomal antigen desmoglein-1 (Dsg1). Previously, we showed that mice injected with autoantibodies from FS patients develop a skin disease that reproduces the clinical, histological, and immunological features of FS, indicating that autoantibodies play an essential role in the development of this disease. The purpose of this study was to characterize the autoimmune T-cell response associated with FS. We provide here the first evidence, to our knowledge, that the great majority of FS patients have circulating T lymphocytes that specifically proliferate in response to the extracellular domain of Dsg1. Long-term T cells developed from these patients also responded to Dsg1, and this antigen-specific response was shown to be restricted to HLA-DR molecules. These Dsg1-reactive FS T cells exhibited a CD4-positive memory T-cell phenotype and produced a T helper 2-like cytokine profile. These findings represent the initial steps in defining the role of T cells in FS autoimmunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.