ArticleInfection and immunity2000
MTSA-10, the product of the Rv3874 gene of Mycobacterium tuberculosis, elicits tuberculosis-specific, delayed-type hypersensitivity in guinea pigs.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 68 citations in OpenAlex.
- Enzyme-linked immunospot and tuberculin skin testing to detect latent tuberculosis infection.American journal of respiratory and critical care medicine · 2005Trial
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- Evaluation of Three Commercial Interferon-γ Assays in a Bovine Tuberculosis Free Population.Frontiers in veterinary science · 2021Article
- Article
- The impact of maternal infection with Mycobacterium tuberculosis on the infant response to bacille Calmette-Guérin immunization.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- The ID93 tuberculosis vaccine candidate does not induce sensitivity to purified protein derivative.Clinical and vaccine immunology : CVI · 2014Article
- Proteomic analysis of purified protein derivative of Mycobacterium tuberculosis.Clinical proteomics · 2013Article
- Virulence factors of the Mycobacterium tuberculosis complex.Virulence · 2013Review
- Purified protein derivatives of tuberculin--past, present, and future.FEMS immunology and medical microbiology · 2012Review
- Use of recombinant purified protein derivative (PPD) antigens as specific skin test for tuberculosis.The Indian journal of medical research · 2012Article
- Three protein cocktails mediate delayed-type hypersensitivity responses indistinguishable from that elicited by purified protein derivative in the guinea pig model of Mycobacterium tuberculosis infection.Infection and immunity · 2011Article
- Mycobacterium tuberculosis MycP1 protease plays a dual role in regulation of ESX-1 secretion and virulence.Cell host & microbe · 2010Article
- Serodiagnostic efficacy of Mycobacterium tuberculosis 30/32-kDa mycolyl transferase complex, ESAT-6, and CFP-10 in patients with active tuberculosis.Archivum immunologiae et therapiae experimentalis · 2010Article
- Identification of Mycobacterium tuberculosis vaccine candidates using human CD4+ T-cells expression cloning.Vaccine · 2009Article
- Article
- Diagnosis of tuberculous meningitis due to detection of ESAT-6-specific gamma interferon production in cerebrospinal fluid enzyme-linked immunospot assay.Clinical and vaccine immunology : CVI · 2008Article
- Detection of natural infection with Mycobacterium intracellulare in healthy wild-caught Chacma baboons (Papio ursinus) by ESAT-6 and CFP-10 IFN-gamma ELISPOT tests following a tuberculosis outbreak.BMC microbiology · 2008Article
- Article
- Cytolytic CD8+ T cells recognizing CFP10 are recruited to the lung after Mycobacterium tuberculosis infection.The Journal of experimental medicine · 2004Article
- Comparative analysis of B- and T-cell epitopes of Mycobacterium leprae and Mycobacterium tuberculosis culture filtrate protein 10.Infection and immunity · 2004Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
In a search for new skin test reagents specific for tuberculosis, we found that the antigen encoded by gene Rv3874 of Mycobacterium tuberculosis elicited delayed-type hypersensitivity in M. tuberculosis-infected guinea pigs but not in control animals immunized with Mycobacterium bovis bacillus Calmette-Guérin (BCG) or Mycobacterium avium. The antigen, which was named MTSA-10 (for M. tuberculosis-specific antigen 10), is a prime candidate for a component of a new tuberculin that will allow discrimination by a skin test of latent M. tuberculosis infection from vaccination with BCG or from sensitization with environmental, nontuberculous mycobacteria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.