ArticleInfection and immunity2000
Comparison of the roles of calcineurin in physiology and virulence in serotype D and serotype A strains of Cryptococcus neoformans.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 74 citations in OpenAlex.
- Cryptococcus neoformans in organ transplant recipients: impact of calcineurin-inhibitor agents on mortality.The Journal of infectious diseases · 2007Trial
- Cryptococcal Meningitis Treatment Beyond HIV: Recognizing the Need for Individualized Immune-Based Strategies.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025Article
- Transcriptional and Post-Translational Roles of Calcineurin in Cationic Stress and Glycerol Biosynthesis inJournal of fungi (Basel, Switzerland) · 2024Article
- A critical role of calcineurin in stress responses, hyphal formation, and virulence of the pathogenic fungus Trichosporon asahii.Scientific reports · 2022Article
- Gene, virulence and related regulatory mechanisms inActa biochimica et biophysica Sinica · 2022Review
- Development of an efficient gene-targeting system for elucidating infection mechanisms of the fungal pathogen Trichosporon asahii.Scientific reports · 2021Article
- Roles for Stress Response and Cell Wall Biosynthesis Pathways in Caspofungin Tolerance inGenetics · 2019Article
- Dissecting the Roles of the Calcineurin Pathway in Unisexual Reproduction, Stress Responses, and Virulence inGenetics · 2018Article
- Virulence Factors as Targets for Anticryptococcal Therapy.Journal of fungi (Basel, Switzerland) · 2016Review
- Identification of QTLs Associated with Virulence Related Traits and Drug Resistance in Cryptococcus neoformans.G3 (Bethesda, Md.) · 2016Article
- Regulatory roles of phosphorylation in model and pathogenic fungi.Medical mycology · 2016Review
- Unisexual reproduction reverses Muller's ratchet.Genetics · 2014Article
- Cryptococcus gattii infections.Clinical microbiology reviews · 2014Review
- Genetic bypass of Aspergillus nidulans crzA function in calcium homeostasis.G3 (Bethesda, Md.) · 2013Article
- Calcineurin governs thermotolerance and virulence of Cryptococcus gattii.G3 (Bethesda, Md.) · 2013Article
- On the Roles of Calcineurin in Fungal Growth and Pathogenesis.Current fungal infection reports · 2010Article
- Variability of phenotypic traits in Cryptococcus varieties and species and the resulting implications for pathogenesis.Future microbiology · 2010Review
- Identification of possible targets of the Aspergillus fumigatus CRZ1 homologue, CrzA.BMC microbiology · 2010Article
- Regulatory diversity of TUP1 in Cryptococcus neoformans.Eukaryotic cell · 2009Article
- Signalling pathways in the pathogenesis of Cryptococcus.Cellular microbiology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
The calcineurin gene was cloned and disrupted in serotype D strains of Cryptococcus neoformans. Serotype A and serotype D calcineurin mutants were inviable at 37 degrees C and avirulent in mice, whereas only serotype A mutants were cation stress sensitive. Thus, calcineurin plays conserved and divergent roles in serotype A and serotype D strains.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.