ArticleInfection and immunity2000
Acquired immunity to Chlamydia pneumoniae is dependent on gamma interferon in two mouse strains that initially differ in this respect after primary challenge.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 38 citations in OpenAlex.
- Biomarkers in the Management of Difficult Asthma.Current topics in medicinal chemistry · 2016Review
- Effect of age and vaccination on extent and spread of Chlamydia pneumoniae infection in C57BL/6 mice.Immunity & ageing : I & A · 2012Article
- Temporal delay of peak T-cell immunity determines Chlamydia pneumoniae pulmonary disease in mice.Infection and immunity · 2008Article
- Genetic control of susceptibility to pulmonary infection with Chlamydia pneumoniae in the mouse.Genes and immunity · 2008Article
- Host cell responses to Chlamydia pneumoniae in gamma interferon-induced persistence overlap those of productive infection and are linked to genes involved in apoptosis, cell cycle, and metabolism.Infection and immunity · 2007Article
- Age alterations in extent and severity of experimental intranasal infection with Chlamydophila pneumoniae in BALB/c mice.Infection and immunity · 2005Article
- Telithromycin treatment of chronic Chlamydia pneumoniae infection in C57BL/6J mice.Antimicrobial agents and chemotherapy · 2004Article
- Identification of Chlamydia pneumoniae-derived mouse CD8 epitopes.Infection and immunity · 2002Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of gamma interferon (IFN-gamma) in a Chlamydia pneumoniae mouse model was studied by in vivo neutralization in two inbred mouse strains. During primary C. pneumoniae infection, neutralization of IFN-gamma increased both the numbers of bacteria and the pneumonia score in the lungs of C57BL/6 mice but not BALB/c mice. During reinfection, the bacterial counts in the lungs were increased by IFN-gamma neutralization in both mouse strains. Thus, the effect of IFN-gamma neutralization was dependent on the genetic background in primary infection. However, IFN-gamma appeared to be equally important in both mouse strains during reinfection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.