ArticleInfection and immunity2000
Phagocytosed Bordetella pertussis fails to survive in human neutrophils.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- Avirulent phenotype promotesEmerging microbes & infections · 2023Article
- Article
- Long Lasting Antibodies From Convalescent Pertussis Patients Induce ROS Production and Bacterial Killing by Human Neutrophils.Frontiers in cellular and infection microbiology · 2022Article
- Transcriptional profiling of human macrophages during infection withRNA biology · 2020Article
- Review
- Bordetella adenylate cyclase toxin is a unique ligand of the integrin complement receptor 3.eLife · 2015Article
- Review of the neutrophil response to Bordetella pertussis infection.Pathogens and disease · 2015Review
- Article
- Immunization of teenagers with a fifth dose of reduced DTaP-IPV induces high levels of pertussis antibodies with a significant increase in opsonophagocytic activity.Clinical and vaccine immunology : CVI · 2011Article
- Decreased leukocyte accumulation and delayed Bordetella pertussis clearance in IL-6-/- mice.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Article
- Bordetella evades the host immune system by inducing IL-10 through a type III effector, BopN.The Journal of experimental medicine · 2009Article
- Pertussis toxin inhibits early chemokine production to delay neutrophil recruitment in response to Bordetella pertussis respiratory tract infection in mice.Infection and immunity · 2008Article
- Opsonophagocytic activity and other serological indications of Bordetella pertussis infection in military recruits in Norway.Clinical and vaccine immunology : CVI · 2007Article
- A dual fluorescence flow cytometric analysis of bacterial adherence to mammalian host cells.Journal of microbiological methods · 2007Article
- Pertussis toxin and lipopolysaccharide influence phagocytosis of Bordetella pertussis by human monocytes.Infection and immunity · 2001Article
- Neutralizing antibodies to adenylate cyclase toxin promote phagocytosis of Bordetella pertussis by human neutrophils.Infection and immunity · 2000Article
- Characterization of bactericidal immune responses following vaccination with acellular pertussis vaccines in adults.Infection and immunity · 2000Article
- Bordetella pertussis virulence factors affect phagocytosis by human neutrophils.Infection and immunity · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Previous studies have reported that phagocytosed Bordetella pertussis survives in human neutrophils. This issue has been reexamined. Opsonized or unopsonized bacteria expressing green fluorescent protein (GFP) were incubated with adherent human neutrophils. Phagocytosis was quantified by fluorescence microscopy, and the viability of phagocytosed bacteria was determined by colony counts following treatment with polymyxin B to kill extracellular bacteria. Only 1 to 2% of the phagocytosed bacteria remained viable. Opsonization with heat-inactivated immune serum reduced the amount of attachment and phagocytosis of the bacteria but did not alter survival rates. In contrast to previous reports, these data suggest that phagocytosed B. pertussis bacteria are killed by human neutrophils.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.