ArticleInfection and immunity2000
The tprK gene is heterogeneous among Treponema pallidum strains and has multiple alleles.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed, 103 citations in OpenAlex.
- The Global Syphilis Epidemic: Turning the Tide.Sexually transmitted diseases · 2026Article
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- In-Depth Proteome Coverage of In Vitro-CulturedJournal of proteome research · 2024Article
- Genomic Epidemiology of Treponema pallidum and Circulation of Strains With Diminished tprK Antigen Variation Capability in Seattle, 2021-2022.The Journal of infectious diseases · 2024Article
- Proteomic analysis of theFrontiers in microbiology · 2024Article
- Deep proteome coverage advances knowledge of Treponema pallidum protein expression profiles during infection.Scientific reports · 2023Article
- Insights into the protective immune response by immunization with full-length recombinant TprK protein: cellular and humoral responses.NPJ vaccines · 2023Article
- Longitudinal Variations in theMicrobiology spectrum · 2023Article
- Treponema pallidum subsp. pallidum with an Artificially impaired TprK antigenic variation system is attenuated in the Rabbit model of syphilis.PLoS pathogens · 2023Article
- Article
- Syphilis vaccine: challenges, controversies and opportunities.Frontiers in immunology · 2023Review
- Full-length TprK of Treponema pallidum subsp. pallidum in lipid nanodiscs is a monomeric porin.Enzyme and microbial technology · 2022Article
- Article
- Comparative genomics and full-length Tprk profiling of Treponema pallidum subsp. pallidum reinfection.PLoS neglected tropical diseases · 2020Article
- The pan-genome of Treponema pallidum reveals differences in genome plasticity between subspecies related to venereal and non-venereal syphilis.BMC genomics · 2020Article
- Article
- Insights into the genetic variation profile of tprK in Treponema pallidum during the development of natural human syphilis infection.PLoS neglected tropical diseases · 2019Article
- Profile of the tprK gene in primary syphilis patients based on next-generation sequencing.PLoS neglected tropical diseases · 2019Article
- Complete genome sequences of two strains of Treponema pallidum subsp. pertenue from Ghana, Africa: Identical genome sequences in samples isolated more than 7 years apart.PLoS neglected tropical diseases · 2017Article
- A defined syphilis vaccine candidate inhibits dissemination of Treponema pallidum subspecies pallidum.Nature communications · 2017Article
5 more citing papers are in PubMed but not listed here.
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5 authors at 1 institution in 1 country.
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Abstract
We have previously shown that the TprK antigen of T. pallidum, Nichols strain, is predominantly expressed in treponemes obtained 10 days after infection and that the hydrophilic domain of TprK is a target of opsonic antibodies and confers significant protection against homologous challenge. The T. pallidum genome sequence reported the presence of a single copy of the tprK gene in the Nichols strain. In the present study we demonstrate size heterogeneity in the central portions of the TprK hydrophilic domains of 14 treponemal isolates. Sequence analysis of the central domains and the complete open reading frames (ORFs) of the tprK genes confirms this heterogeneity. Further, multiple tprK sequences were found in the Nichols-defined tprK locus in three isolates (Sea 81-4, Bal 7, and Bal 73-1). In contrast, only a single tprK sequence could be identified in this locus in the Nichols strain. Alignment of the DNA and deduced amino acid sequences of the whole tprK ORFs shows the presence of seven discrete variable domains flanked by highly conserved regions. We hypothesize that these heterogeneous regions may be involved in antigenic heterogeneity and, in particular, evasion of the immune response. The presence of different tprK alleles in the tprK locus strongly suggests the existence of genetically different subpopulations within treponemal isolates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.