ArticleInfection and immunity2000
Mucosally induced immunoglobulin E-associated inflammation in the respiratory tract.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 45 citations in OpenAlex.
- Effect of Inoculation Volume on a Mouse Model of Influenza Virus Infected with the Same Viral Load.Vaccines · 2025Article
- Mast cells partially contribute to mucosal adjuvanticity of surfactin in mice.Immunity, inflammation and disease · 2018Article
- Factors associated with bronchiectasis in patients with moderate-severe chronic obstructive pulmonary disease.Medicine · 2016Article
- A nonhuman primate toxicology and immunogenicity study evaluating aerosol delivery of AERAS-402/Ad35 vaccine: Evidence for transient t cell responses in peripheral blood and robust sustained responses in the lungs.Human vaccines & immunotherapeutics · 2014Article
- Article
- Effective induction of protective systemic immunity with nasally administered vaccines adjuvanted with IL-1.Vaccine · 2010Article
- NK cells interfere with the generation of resistance against mycoplasma respiratory infection following nasal-pulmonary immunization.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Intranasal delivery of cholera toxin induces th17-dominated T-cell response to bystander antigens.PloS one · 2009Article
- Immunity to a self-derived, channel-forming peptide in the respiratory tract.Clinical and vaccine immunology : CVI · 2008Article
- Oral and nasal sensitization promote distinct immune responses and lung reactivity in a mouse model of peanut allergy.The American journal of pathology · 2005Article
- Local and systemic antibody responses in mice immunized intranasally with native and detergent-extracted outer membrane vesicles from Neisseria meningitidis.Infection and immunity · 2004Article
- Role of T cells in the adjuvant effect of Bacillus firmus on the immune system of mice: intranasal and intratracheal immunization study with ovalbumin.Folia microbiologica · 2003Article
- Influence of intravenous anesthesia on mucosal and systemic antibody responses to nasal vaccines.Infection and immunity · 2002Article
- Evaluation of events occurring at mucosal surfaces: techniques used to collect and analyze mucosal secretions and cells.Clinical and diagnostic laboratory immunology · 2002Review
- Cytokines as adjuvants for the induction of anti-human immunodeficiency virus peptide immunoglobulin G (IgG) and IgA antibodies in serum and mucosal secretions after nasal immunization.Journal of virology · 2002Article
- Immunoglobulin A (IgA) responses and IgE-associated inflammation along the respiratory tract after mucosal but not systemic immunization.Infection and immunity · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
The purpose of the present study was to determine the immunologic responses, particularly immunopathologic reactions, associated with nasal immunization with the mucosal adjuvant, cholera toxin (CT). BALB/c mice were nasally immunized with tetanus toxoid (TT) combined with CT, and the responses of these mice were determined. After nasal immunization, mice produce a serum antibody response, primarily of the immunoglobulin G (IgG) isotype of predominantly IgG1 subclass, against both TT and CT. Along with the antibody responses, we also found that inflammatory reactions, which could be potentially fatal, developed within the lung. Furthermore, IgE responses were also induced after nasal immunization, and these responses were associated with the detection of interleukin 5 in the serum. Thus, nasal immunization with TT plus CT likely results in the activation of Th2 cells, which may contribute to serious immunopathologic reactions in the lung.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.