ArticleInfection and immunity2000
Adherence of platelets to Candida species in vivo.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Analysis of the association of neutrophil-to-lymphocyte ratio, MPV-to-platelet ratio, and clinical risk factors for mortality in ICU patients with candidemia: a 10-year retrospective analysis.BMC infectious diseases · 2025Observational
- Beyond hemostasis, the immunomodulatory nature of platelets.Research and practice in thrombosis and haemostasis · 2025Review
- Antifungal Innate Immunity.Advances in experimental medicine and biology · 2025Review
- Immunity to pathogenic mucosal C. albicans infections mediated by oral megakaryocytes activated by IL-17 and candidalysin.Mucosal immunology · 2024Article
- Rapid detection of pathogenic fungi from coastal population with respiratory infections using microfluidic chip technology.BMC infectious diseases · 2024Article
- Knockdown of miR‑205‑5p alleviates the inflammatory response in allergic rhinitis by targeting B‑cell lymphoma 6.Molecular medicine reports · 2021Article
- GP IIb/IIIa-Mediated Platelet Activation and Its Modulation of the Immune Response of Monocytes AgainstFrontiers in cellular and infection microbiology · 2021Article
- How Fungal Glycans Modulate Platelet Activation via Toll-Like Receptors Contributing to the Escape ofAntibiotics (Basel, Switzerland) · 2020Review
- Stepping Up to the Plate(let) against Candida albicans.Infection and immunity · 2020Article
- Significant Differences in Host-Pathogen Interactions Between Murine and Human Whole Blood.Frontiers in immunology · 2020Article
- Comparative Analysis of Blood Clot, Plasma Rich in Growth Factors and Platelet-Rich Fibrin Resistance to Bacteria-Induced Fibrinolysis.Microorganisms · 2019Article
- Fungal Chitin Reduces Platelet Activation Mediated via TLR8 Stimulation.Frontiers in cellular and infection microbiology · 2019Article
- Candida: Platelet Interaction and Platelet Activity in vitro.Journal of innate immunity · 2019Article
- Review
- Immune defence against Candida fungal infections.Nature reviews. Immunology · 2015Review
- Antifungal innate immunity: recognition and inflammatory networks.Seminars in immunopathology · 2015Review
- Integrated inference and evaluation of host-fungi interaction networks.Frontiers in microbiology · 2015Article
- In vitro and in vivo antifungal activities of selected Cameroonian dietary spices.BMC complementary and alternative medicine · 2014Article
- Urea amidolyase (DUR1,2) contributes to virulence and kidney pathogenesis of Candida albicans.PloS one · 2012Article
- Effect of farnesol on a mouse model of systemic candidiasis, determined by use of a DPP3 knockout mutant of Candida albicans.Infection and immunity · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The in vivo interactions of platelets with Candida species yeast cells were investigated in a murine model. Mice were injected intravenously via the lateral caudal vein, and blood drawn by periorbital puncture was collected in phosphate-buffered saline-formaldehyde to avoid in vitro platelet activation. The study of the clearance of blastoconidia of Candida albicans and Candida glabrata showed that these cells disappeared quickly from the bloodstream. Microscopic observation of blood samples, stained by Calcofluor white or May Grunwald Giemsa, demonstrated the rapid attachment of platelets to fungal elements of all the Candida spp. tested. The attachment of murine platelets to C. albicans cells, observed by scanning electron microscopy, revealed morphological changes. The platelets lost their discoid shape, generated pseudopodia, and flattened against the yeast cells. The reversibility of platelet binding to C. albicans by chelating agents suggests a cation-dependent link. In contrast, the fixation of C. glabrata and Candida tropicalis was not modified by chelating agents. The mechanisms involved in the in vivo adherence of platelets to Candida cells may therefore differ according to the species of Candida.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.