ArticleInfection and immunity2000
Defective hyphal development and avirulence caused by a deletion of the SSK1 response regulator gene in Candida albicans.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
65 citing papers in PubMed, 141 citations in OpenAlex.
- Stress-Activated Protein Kinase Pathways as Potential Targets for the Development of New Antifungals.Journal of fungi (Basel, Switzerland) · 2026Review
- Stress contingent changes in Hog1 pathway architecture and regulation in Candida albicans.PLoS pathogens · 2024Article
- Polypeptides TargetingJournal of fungi (Basel, Switzerland) · 2023Article
- HYPHAEdelity: a quantitative image analysis tool for assessing peripheral whole colony filamentation.FEMS yeast research · 2022Article
- AoSsk1, a Response Regulator Required for Mycelial Growth and Development, Stress Responses, Trap Formation, and the Secondary Metabolism inJournal of fungi (Basel, Switzerland) · 2022Article
- Development of an Anti-Biofilm Screening Technique Leads to the Discovery of a Peptoid with Efficacy againstACS infectious diseases · 2022Article
- Review
- Multistep Signaling in Nature: A Close-Up ofInternational journal of molecular sciences · 2021Review
- From Jekyll to Hyde: The Yeast-Hyphal Transition ofPathogens (Basel, Switzerland) · 2021Review
- Candida albicans CHK1 gene from two-component system is essential for its pathogenicity in oral candidiasis.Applied microbiology and biotechnology · 2021Article
- Article
- Automated quantification of Candida albicans biofilm-related phenotypes reveals additive contributions to biofilm production.NPJ biofilms and microbiomes · 2020Article
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- Overexpression ofSmall GTPases · 2020Article
- Inhibiting roles of farnesol and HOG in morphological switching ofAmerican journal of translational research · 2020Review
- The influence of N and S poles of static magnetic field (SMF) on Candida albicans hyphal formation and antifungal activity of amphotericin B.Folia microbiologica · 2019Article
- The Transcription Factor Sfp1 Regulates the Oxidative Stress Response inMicroorganisms · 2019Article
- Stress-Activated Protein Kinases in Human Fungal Pathogens.Frontiers in cellular and infection microbiology · 2019Review
- Nutrient and Stress Sensing in Pathogenic Yeasts.Frontiers in microbiology · 2019Review
- The yeasts phosphorelay systems: a comparative view.World journal of microbiology & biotechnology · 2017Review
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
In a previous study, we reported the isolation and characterization of the two-component response regulator SSK1 gene of Candida albicans. This gene is a structural but not a functional homolog of the SSK1 and mcs4(+) genes of Saccharomyces cerevisiae and Schizosaccharomyces pombe, respectively. In the present study, we have constructed and phenotypically characterized Deltassk1 mutants of C. albicans. The results confirmed our previous observation that CaSSK1, unlike SSK1 or mcs4(+), does not regulate cellular responses to either osmotic or oxidative stress. Instead, Deltassk1 null strains showed severely reduced hyphal formation on serum agar and were totally defective in hyphal development on other solid media, such as medium 199 (pH 7.5) and Spider medium. In contrast, under conditions of low nitrogen availability on solid media, Deltassk1 null strains dramatically hyperinvaded the agar. However, while forming germ tubes and hyphae in liquid media similar to those of the wild type, Deltassk1 null strains flocculated in a manner similar to that of Deltachk1 two-component histidine kinase mutants, which we have previously described. Finally, virulence studies indicated that SSK1 is essential for the pathogenesis of C. albicans, suggesting that the Ssk1p response regulator could be a good target for antifungal therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.