ArticleAntimicrobial agents and chemotherapy2000
Identification of a cyclase gene dictating the C-9 stereochemistry of anthracyclines from Streptomyces nogalater.
Article in Antimicrobial agents and chemotherapy, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 42 citations in OpenAlex.
- Discovery of Noncanonical Iron and 2-Oxoglutarate Dependent Enzymes Involved in C-C and C-N Bond Formation in Biosynthetic Pathways.ACS bio & med chem Au · 2025Review
- Xanthomonas citri subsp. citri requires a polyketide cyclase to activate the type III secretion system for virulence.BMC microbiology · 2025Article
- Biochemical and Structural Studies of the Carminomycin 4-Journal of natural products · 2024Article
- A BioBricks Metabolic Engineering Platform for the Biosynthesis of Anthracyclinones inACS synthetic biology · 2022Article
- Biosynthesis of Nature-Inspired Unnatural Cannabinoids.Molecules (Basel, Switzerland) · 2021Review
- Omics Technologies to Understand Activation of a Biosynthetic Gene Cluster in Micromonospora sp. WMMB235: Deciphering Keyicin Biosynthesis.ACS chemical biology · 2019Article
- A Novel Class of Plant Type III Polyketide Synthase Involved in Orsellinic Acid Biosynthesis fromFrontiers in plant science · 2016Article
- Biosynthesis of akaeolide and lorneic acids and annotation of type I polyketide synthase gene clusters in the genome of Streptomyces sp. NPS554.Marine drugs · 2015Article
- Structure of a conserved hypothetical protein, TTHA0849 from Thermus thermophilus HB8, at 2.4 A resolution: a putative member of the StAR-related lipid-transfer (START) domain superfamily.Acta crystallographica. Section F, Structural biology and crystallization communications · 2005Article
- Structure of the polyketide cyclase SnoaL reveals a novel mechanism for enzymatic aldol condensation.The EMBO journal · 2004Article
- Engineering anthracycline biosynthesis toward angucyclines.Antimicrobial agents and chemotherapy · 2003Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nogalamycin is an anthracycline antibiotic produced by Streptomyces nogalater. Its aglycone has a unique stereochemistry (7S, 9S, 10R) compared to that of most other anthracyclines (7S, 9R, 10R). The gene snoaL, encoding a nogalonic acid methyl ester cyclase for nogalamycin, was used to generate nogalamycinone, demonstrating that the single cyclase dictates the C-9 stereochemistry of anthracyclines.
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Registered trials
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