ArticleAntimicrobial agents and chemotherapy2000
Ultrastructure of Achilles tendons of rats treated with ofloxacin and fed a normal or magnesium-deficient diet.
Article in Antimicrobial agents and chemotherapy, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Predictors of primary Achilles tendon ruptures.Sports medicine (Auckland, N.Z.) · 2014Pooled it
- Adjuvant Interventions in Levofloxacin-Exposed Rabbit Achilles Tendons: An Exploratory Controlled Pilot Study with Histopathological and Ultrasonographic Endpoints.Journal of clinical medicine · 2026Article
- Safety analysis of quinolones use in minors-based on the FAERS database.Frontiers in medicine · 2024Article
- Overview of Side-Effects of Antibacterial Fluoroquinolones: New Drugs versus Old Drugs, a Step Forward in the Safety Profile?Pharmaceutics · 2023Review
- Association Between Aortic Aneurysm and Aortic Dissection With Fluoroquinolones Use in Patients With Urinary Tract Infections: A Population-Based Cohort Study.Journal of the American Heart Association · 2022Article
- Current progress of fluoroquinolones-increased risk of aortic aneurysm and dissection.BMC cardiovascular disorders · 2021Review
- Quinolones-Induced Musculoskeletal, Neurological, and Psychiatric ADRs: A Pharmacovigilance Study Based on Data From the Italian Spontaneous Reporting System.Frontiers in pharmacology · 2020Article
- Fluoroquinolones and Aortic Diseases: Is There a Connection.Aorta (Stamford, Conn.) · 2019Article
- Risk of gastrointestinal perforation in patients taking oral fluoroquinolone therapy: An analysis of nationally representative cohort.PloS one · 2017Article
- Safety considerations of fluoroquinolones in the elderly: an update.Drugs & aging · 2010Review
- Spontaneous bilateral Achilles tendon rupture in a patient treated with oral levofloxacin.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2007Article
- Use of fluroquinolone and risk of Achilles tendon rupture: a population-based cohort study.European journal of clinical pharmacology · 2007Article
- Bilateral plantar tendinitis during levofloxacin therapy.British journal of clinical pharmacology · 2006Review
- Efficacy and safety of levofloxacin in the context of other contemporary fluoroquinolones: a review.Current therapeutic research, clinical and experimental · 2003Article
- Fluoroquinolones in the elderly: safety considerations.Drugs & aging · 2003Review
- Synergistic effect of ofloxacin and magnesium deficiency on joint cartilage in immature rats.Antimicrobial agents and chemotherapy · 2002Article
- Safety of fluoroquinolones: An update.The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fluoroquinolones can cause tendinitis and tendon rupture. However, toxicological as well as clinical information on quinolone-induced tendopathy is scarce. We performed extensive electron microscopic studies with Achilles tendon specimens from ofloxacin-treated rats. The drug was given at a dose of 1,200 mg/kg (body weight) orally. Juvenile Wistar rats received one or three oral doses each of 1,200 mg of ofloxacin/kg (body weight)/day. Three days after treatment, the tenocytes of their Achilles tendons showed degenerative alterations, such as multiple vacuoles and vesicles in the cytoplasm that had developed due to swellings and dilatations of cell organelles. Other indications of cell degradation were the occurrence of cell debris and cell detachment from the extracellular matrix accompanied by a loss of cell-matrix interaction. The tenocytes of juvenile Wistar rats that had been treated at day 36 with a single oral dose of 1,200 mg of ofloxacin/kg (body weight) and sacrificed either 3 or 6 months later exhibited similar degenerative alterations. The number of degenerative alterations of tenocytes after ofloxacin treatment was considerably higher in rats that had received a magnesium-deficient diet than in rats with normal magnesium status. Of the adult rats that had been treated once, 5 times, and 10 times with ofloxacin and killed 1 day later, only those with the 10-times treatment showed a significantly increased number of degeneratively altered tenocytes. In summary, effects observed in tendons show similar pathological features as described earlier in cartilage, indicating that quinolone-induced arthropathy and quinolone-induced tendopathy probably are different clinical manifestations of the same toxic effect on cellular components of connective tissue structures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.