ArticleProceedings of the National Academy of Sciences of the United States of America2000
Functional evolution of the Ultrabithorax protein.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 86 citations in OpenAlex.
- The functional evolution of collembolan Ubx on the regulation of abdominal appendage formation.Development genes and evolution · 2024Article
- Article
- A comparative genomic analysis of targets of Hox protein Ultrabithorax amongst distant insect species.Scientific reports · 2016Article
- Mechanisms of Specificity for Hox Factor Activity.Journal of developmental biology · 2016Article
- Rethinking gene regulatory networks in light of alternative splicing, intrinsically disordered protein domains, and post-translational modifications.Frontiers in cell and developmental biology · 2015Article
- Article
- Differential activity of Drosophila Hox genes induces myosin expression and can maintain compartment boundaries.PloS one · 2013Article
- The phylotypic stage as a boundary of modular memory: non mechanistic perspective.Theory in biosciences = Theorie in den Biowissenschaften · 2012Article
- Surprising flexibility in a conserved Hox transcription factor over 550 million years of evolution.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Use with caution: developmental systems divergence and potential pitfalls of animal models.The Yale journal of biology and medicine · 2009Review
- Adaptive changes in the transcription factor HoxA-11 are essential for the evolution of pregnancy in mammals.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- An empirical test for branch-specific positive selection.Genetics · 2008Article
- Context-dependent regulation of Hox protein functions by CK2 phosphorylation sites.Development genes and evolution · 2008Article
- Adaptive evolution of Hox-gene homeodomains after cluster duplications.BMC evolutionary biology · 2006Article
- Wing-to-Leg homeosis by spineless causes apoptosis regulated by Fish-lips, a novel leucine-rich repeat transmembrane protein.Molecular and cellular biology · 2005Article
- Adaptive evolution of HoxA-11 and HoxA-13 at the origin of the uterus in mammals.Proceedings. Biological sciences · 2004Article
- Gene network polymorphism is the raw material of natural selection: the selfish gene network hypothesis.Journal of molecular evolution · 2004Article
- Differential expression patterns of the hox gene are associated with differential growth of insect hind legs.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Article
- Molecular characterization and mapping of ATOH7, a human atonal homolog with a predicted role in retinal ganglion cell development.Mammalian genome : official journal of the International Mammalian Genome Society · 2002Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Hox genes have been implicated as central to the evolution of animal body plan diversity. Regulatory changes both in Hox expression domains and in Hox-regulated gene networks have arisen during the evolution of related taxa, but there is little knowledge of whether functional changes in Hox proteins have also contributed to morphological evolution. For example, the evolution of greater numbers of differentiated segments and body parts in insects, compared with the simpler body plans of arthropod ancestors, may have involved an increase in the spectrum of biochemical interactions of individual Hox proteins. Here, we compare the in vivo functions of orthologous Ultrabithorax (Ubx) proteins from the insect Drosophila melanogaster and from an onychophoran, a member of a sister phylum with a more primitive and homonomous body plan. These Ubx proteins, which have been diverging in sequence for over 540 million years, can generate many of the same gain-of-function tissue transformations and can activate and repress many of the same target genes when expressed during Drosophila development. However, the onychophora Ubx (OUbx) protein does not transform the segmental identity of the embryonic ectoderm or repress the Distal-less target gene. This functional divergence is due to sequence changes outside the conserved homeodomain region. The inability of OUbx to function like Drosophila Ubx (DUbx) in the embryonic ectoderm indicates that the Ubx protein may have acquired new cofactors or activity modifiers since the divergence of the onychophoran and insect lineages.
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