ArticleBritish journal of cancer2000
Promoter region methylation does not account for the frequent loss of expression of the Fas gene in colorectal carcinoma.
Article in British journal of cancer, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 28 citations in OpenAlex.
- Mechanism of Apoptosis Induced by Curcumin in Colorectal Cancer.International journal of molecular sciences · 2019Review
- Epigenetic inactivation of tumour suppressor coding and non-coding genes in human cancer: an update.Open biology · 2017Review
- Promoter hypermethylation and downregulation of the FAS gene may be involved in colorectal carcinogenesis.Oncology letters · 2016Article
- Down-regulation of BAX gene during carcinogenesis and acquisition of resistance to 5-FU in colorectal cancer.Pathology oncology research : POR · 2014Article
- Article
- Fas expression in metastatic osteosarcoma cells is not regulated by CpG island methylation.Oncology research · 2009Article
- Expression of FAP-1 by human colon adenocarcinoma: implication for resistance against Fas-mediated apoptosis in cancer.British journal of cancer · 2004Article
- Proximal versus distal hyperplastic polyps of the colorectum: different lesions or a biological spectrum?Journal of clinical pathology · 2004Article
- Alterations of Fas (APO-1/CD 95) gene and its relationship with p53 in non small cell lung cancer.Oncogene · 2001Article
- Article
- Matrilysin [MMP-7] expression selects for cells with reduced sensitivity to apoptosis.Neoplasia (New York, N.Y.)Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Expression of the apoptosis-promoting Fas gene is frequently reduced or lost during the development of colorectal carcinoma. However, loss of heterozygosity at the Fas locus or Fas gene rearrangements do not account for the loss of expression of Fas, raising the possibility that methylation of the Fas promoter may inhibit gene expression in colorectal carcinomas. We have examined the Fas promoter region CpG island for evidence of hypermethylation in colorectal tumours. Forty-seven specimens of colorectal adenoma and carcinoma, as well as six samples of normal colonic mucosa, were examined by Southern blotting for methylation at HpaII and Cfol sites in this region. No methylation was detected in any of the specimens, suggesting that hypermethylation is not primarily responsible for the loss of expression of the Fas gene during colorectal tumorigenesis.
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