ArticleNucleic acids research2000
Characterization of Drosophila OVO protein DNA binding specificity using random DNA oligomer selection suggests zinc finger degeneration.
Article in Nucleic acids research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Female germline expression of OVO transcription factor bridges Drosophila generations.G3 (Bethesda, Md.) · 2025Article
- OVO positively regulates essential maternal pathways by binding near the transcriptional start sites in theeLife · 2024Article
- OVO Positively Regulates Essential Maternal Pathways by Binding Near the Transcriptional Start Sites in thebioRxiv : the preprint server for biology · 2024Article
- Crosstalk between chromatin and Shavenbaby defines transcriptional output along the Drosophila intestinal stem cell lineage.iScience · 2024Article
- Functional characterization of BmOVOs in silkworm, Bombyx mori.BMC genomics · 2019Article
- Article
- OVOL2 antagonizes TGF-β signaling to regulate epithelial to mesenchymal transition during mammary tumor metastasis.Oncotarget · 2017Article
- Genome-wide analyses of Shavenbaby target genes reveals distinct features of enhancer organization.Genome biology · 2013Article
- Germ cell sex determination: a collaboration between soma and germline.Current opinion in cell biology · 2010Review
- Ovol1 represses its own transcription by competing with transcription activator c-Myb and by recruiting histone deacetylase activity.Nucleic acids research · 2007Article
- Core promoter sequences contribute to ovo-B regulation in the Drosophila melanogaster germline.Genetics · 2005Article
- The LEF1/beta -catenin complex activates movo1, a mouse homolog of Drosophila ovo required for epidermal appendage differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Sex determination signals control ovo-B transcription in Drosophila melanogaster germ cells.Genetics · 2002Article
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2 authors.
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Abstract
The Drosophila melanogaster ovo locus codes for several tissue- and stage-specific proteins that all possess a common C-terminal array of four C(2)H(2)zinc fingers. Three fingers conform to the motif framework and are evolutionarily conserved; the fourth diverges considerably. The ovo genetic function affects germ cell viability, sex identity and oogenesis, while the overlapping svb function is a key selector for epidermal structures under the control of wnt and EGF receptor signaling. We isolated synthetic DNA oligomers bound by the OVO zinc finger array from a high complexity starting population and derived a statistically significant 9 bp long DNA consensus sequence, which is nearly identical to a consensus derived from several Drosophila genes known or suspected of being regulated by the ovo function in vivo. The DNA consensus recognized by Drosophila OVO protein is atypical for zinc finger proteins in that it does not conform to many of the 'rules' for the interaction of amino acid contact residues and DNA bases. Additionally, our results suggest that only three of the OVO zinc fingers contribute to DNA-binding specificity.
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