ArticleMolecular biology of the cell2000
Myosin-II tails confer unique functions in Schizosaccharomyces pombe: characterization of a novel myosin-II tail.
Article in Molecular biology of the cell, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 57 citations in OpenAlex.
- Comparative Analysis of the Roles of Non-muscle Myosin-IIs in Cytokinesis in Budding Yeast, Fission Yeast, and Mammalian Cells.Frontiers in cell and developmental biology · 2020Review
- Molecular form and function of the cytokinetic ring.Journal of cell science · 2019Review
- Distinct Roles of Myosin-II Isoforms in Cytokinesis under Normal and Stressed Conditions.iScience · 2019Article
- Mechanisms of contractile ring tension production and constriction.Biophysical reviews · 2018Review
- Coarse-grained simulations of actomyosin rings point to a nodeless model involving both unipolar and bipolar myosins.Molecular biology of the cell · 2018Article
- Fungal Morphogenesis, from the Polarized Growth of Hyphae to Complex Reproduction and Infection Structures.Microbiology and molecular biology reviews : MMBR · 2018Review
- Fission yeast Myo2: Molecular organization and diffusion in the cytoplasm.Cytoskeleton (Hoboken, N.J.) · 2018Article
- Interacting-heads motif has been conserved as a mechanism of myosin II inhibition since before the origin of animals.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Recent advances in cytokinesis: understanding the molecular underpinnings.F1000Research · 2018Review
- A node organization in the actomyosin contractile ring generates tension and aids stability.Molecular biology of the cell · 2017Article
- Mechanoregulated inhibition of formin facilitates contractile actomyosin ring assembly.Nature communications · 2017Article
- Nanoscale architecture of theeLife · 2017Article
- Fission yeast myosin Myo2 is down-regulated in actin affinity by light chain phosphorylation.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Response to Zambon et al.Current biology : CB · 2017Article
- Molecular organization of cytokinesis nodes and contractile rings by super-resolution fluorescence microscopy of live fission yeast.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Three myosins contribute uniquely to the assembly and constriction of the fission yeast cytokinetic contractile ring.Current biology : CB · 2015Article
- The novel proteins Rng8 and Rng9 regulate the myosin-V Myo51 during fission yeast cytokinesis.The Journal of cell biology · 2014Article
- UCS protein Rng3p is essential for myosin-II motor activity during cytokinesis in fission yeast.PloS one · 2013Article
- Assembly and architecture of precursor nodes during fission yeast cytokinesis.The Journal of cell biology · 2011Article
- Dividing the spoils of growth and the cell cycle: The fission yeast as a model for the study of cytokinesis.Cytoskeleton (Hoboken, N.J.) · 2011Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Schizosaccharomyces pombe has two myosin-IIs, Myo2p and Myp2p, which both concentrate in the cleavage furrow during cytokinesis. We studied the phenotype of mutant myosin-II strains to examine whether these myosins have overlapping functions in the cell. myo2(+) is essential. myp2(+) cannot rescue loss of myo2(+) even at elevated levels of expression. myp2(+) is required under specific nutritional conditions; thus myo2(+) cannot rescue under these conditions. Studies with chimeras show that the tails rather than the structurally similar heads determine the gene-specific functions of myp2(+) and myo2(+). The Myo2p tail is a rod-shaped coiled-coil dimer that aggregates in low salt like other myosin-II tails. The Myp2p tail is monomeric in high salt and is insoluble in low salt. Biophysical properties of the full-length Myp2p tail and smaller subdomains indicate that two predicted coiled-coil regions fold back on themselves to form a rod-shaped antiparallel coiled coil. This suggests that Myp2p is the first type II myosin with only one head. The C-terminal two-thirds of Myp2p tail are essential for function in vivo and may interact with components of the salt response pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.