ReviewAnnals of surgery2000
Cell surface molecules and their prognostic values in assessing colorectal carcinomas.
Review in Annals of surgery, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed.
- Transient variations in the serum concentrations of cell adhesion molecules following retroperitoneal laparoscopic and open radical nephrectomy for localized renal-cell carcinoma.Journal of endourology · 2012Trial
- Prognostic value of brown adipocyte-related genes in colorectal cancer: a multi-omics and Mendelian randomization study.Discover oncology · 2025Article
- Nectins and Nectin-like Molecules in Colorectal Cancer: Role in Diagnostics, Prognostic Values, and Emerging Treatment Options: A Literature Review.Diagnostics (Basel, Switzerland) · 2022Review
- Diclofenac down-regulates COX-2 induced expression of CD44 and ICAM-1 in human HT29 colorectal cancer cells.Naunyn-Schmiedeberg's archives of pharmacology · 2021Article
- Multivalent conjugation of antibody to dendrimers for the enhanced capture and regulation on colon cancer cells.Scientific reports · 2015Article
- Exploring cancer metastasis prevention strategy: interrupting adhesion of cancer cells to vascular endothelia of potential metastatic tissues by antibody-coated nanomaterial.Journal of nanobiotechnology · 2015Article
- Role of β1-Integrin in Colorectal Cancer: Case-Control Study.Annals of coloproctology · 2014Article
- Invasion and metastasis in the viewpoint of cell adhesive molecules.Annals of coloproctology · 2014Article
- Synthesis, spectral characterization, and in vitro cellular activities of metapristone, a potential cancer metastatic chemopreventive agent derived from mifepristone (RU486).The AAPS journal · 2014Article
- Article
- Prognostic value of β1 integrin expression in colorectal liver metastases.International journal of clinical and experimental pathology · 2014Article
- Interleukin-8 is associated with adhesion, migration and invasion in human gastric cancer SCG-7901 cells.Medical oncology (Northwood, London, England) · 2012Article
- Mechanisms regulating colorectal cancer cell metastasis into liver (Review).Oncology letters · 2012Article
- C2-O-sLeX glycoproteins are E-selectin ligands that regulate invasion of human colon and hepatic carcinoma cells.PloS one · 2011Article
- Cell surface markers in colorectal cancer prognosis.International journal of molecular sciences · 2010Review
- Sialylated Lewis x antigen bearing glycoproteins in human plasma.Journal of proteome research · 2010Article
- Prognostic impact of the expression of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and ALDH1 in colorectal cancer.British journal of cancer · 2010Article
- In vivo tumor cell adhesion in the pulmonary microvasculature is exclusively mediated by tumor cell--endothelial cell interaction.BMC cancer · 2010Article
- The effects of mechanical forces on intestinal physiology and pathology.Cellular signalling · 2009Review
- Higher CO2-insufflation pressure inhibits the expression of adhesion molecules and the invasion potential of colon cancer cells.World journal of gastroenterology · 2009Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCarcinomas of the colon and rectum are the third leading cause of cancer-related deaths. Although advances in the surgical treatment of primary colorectal cancers have lead to improvements in patient survival at early tumor stages, treatment of more progressive cancers has not resulted in dramatic improvements in patient survival. However, the selection of patient subgroups based on their prognosis and other characteristics could result in improved outcomes from adjuvant therapies in patients with Dukes B and C carcinomas.
methodsThe authors reviewed the available data on the value of cell surface molecules in assessing the prognosis of colorectal carcinomas, paying specific attention to the evaluation of statistical analysis and multivariate procedures.
resultsCell surface molecules have been identified on colorectal carcinoma cells whose expression appears to be related to malignant transformation, tumor progression, or patient prognosis. Among these cell surface molecules, various cell adhesion molecules, growth factor receptors, proteinases, and their receptors and inhibitors have been identified as potentially useful prognostic markers.
conclusionsAlthough data exist on the prognostic values of certain cell surface markers, the use of multivariate analysis for the identification of valuable prognostic factors remains uncommon. Using reproducible and standardized multivariate analysis procedures, new tumor markers should be carefully examined for their biologic and prognostic relevance before being considered as potentially useful in the management of colorectal cancers.
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