ArticleJournal of anatomy1999
Morphometric and ultrastructural changes with ageing in mouse peripheral nerve.
Article in Journal of anatomy, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
81 citing papers in PubMed, 1 synthesis or guideline pooled it, 179 citations in OpenAlex.
- Consequences of Aging on Bone.Aging and disease · 2023Pooled it
- Presynaptic compensation sustains neuromuscular transmission in the mouse diaphragm at a late stage of aging.Biogerontology · 2026Article
- Alterations in sensory and motor nerve conduction associated with age and osteoarthritis in cats are correlated with functional impairment and somatosensory sensitization.Scientific reports · 2026Article
- Article
- A novel sensor-based real-time tracking game for assessing ankle proprioceptive effects on sensorimotor performance.Biomedical engineering online · 2025Article
- Fibroblast growth factor signaling induces a chondrocyte-like state of peripheral nerve fibroblast during aging.Nature communications · 2025Article
- Aging and Corneal Nerve Health: Mechanisms of Degeneration and Emerging Therapies for the Cornea.Cells · 2025Review
- Rejuvenation alleviates prolonged postsurgical pain in aging mice by mitigating inflammaging.Pain · 2025Article
- The effect of age on ankle versus hip proprioceptive contribution in balance recovery: application of vibratory stimulation for altering proprioceptive performance.Biomedical engineering letters · 2025Article
- Age‑related changes in endoplasmic reticulum stress response‑associated protein expression in rat tibial nerves.Biomedical reports · 2025Article
- Nerve cross-sectional area from childhood to old age: A high-resolution nerve ultrasound study.European journal of neurology · 2024Article
- Age-dependent small fiber neuropathy: Mechanistic insights from animal models.Experimental neurology · 2024Review
- Schwann Cells as Orchestrators of Nerve Repair: Implications for Tissue Regeneration and Pathologies.Cold Spring Harbor perspectives in biology · 2024Review
- Assessing the role of ankle and hip joint proprioceptive information in balance recovery using vibratory stimulation.Heliyon · 2024Article
- Article
- Age-related alterations in the cardiovascular responses to acute exercise in males and females: role of the exercise pressor reflex.Frontiers in physiology · 2023Review
- Aging affects the number and morphological heterogeneity of rat phrenic motor neurons and phrenic motor axons.Physiological reports · 2023Article
- Repair of Long Nerve Defects with a New Decellularized Nerve Graft in Rats and in Sheep.Cells · 2022Article
- Evaluation of anatomical and histological characteristics of human peripheral nerves: as an effort to develop an efficient allogeneic nerve graft.Cell and tissue banking · 2022Article
- Improved acquisition of contact heat evoked potentials with increased heating ramp.Scientific reports · 2022Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Qualitative and quantitative information is reported on the morphological changes that occur in nerve fibres and nonneuronal cells of peripheral nerve during the lifetime of the mouse. Tibial nerves of mice aged 6-33 mo were studied. With ageing, collagen accumulates in the perineurium and lipid droplets in the perineurial cells. Macrophages and mast cells increase in number, and onion bulbs and collagen pockets are frequently present. Schwann cells associated with myelinated fibres (MF) slightly decrease in number in parallel with an increase of the internodal length from 6 to 12 mo, but increase in older nerves when demyelination and remyelination are common. The unmyelinated axon to myelinated fibre (UA/MF) ratio was about 2 until 12 mo, decreasing to 1.6 by 27 mo. In older mice, the loss of nerve fibres involves UA (50% loss of 27-33 mo cf. 6 mo) more markedly than MF (35%). In aged nerves wide incisures and infolded or outfolded myelin loops are frequent, resulting in an increased irregularity in the morphology of fibres along the internodes. In the mouse there is an adult time period, 12-20 mo, during which several features of degeneration progressively appear, and an ageing period from 20 mo upwards when the nerve suffers a general disorganisation and marked fibre loss.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.