ArticleJournal of anatomy1999
Immuno-inflammatory cell dynamics during cutaneous wound healing.
Article in Journal of anatomy, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Review
- Host CD3Frontiers in microbiology · 2023Article
- Cutaneous Wound Healing: A Review about Innate Immune Response and Current Therapeutic Applications.Mediators of inflammation · 2022Review
- Effects of immune cells on mesenchymal stem cells during fracture healing.World journal of stem cells · 2021Review
- Comprehensive characterization of myeloid cells during wound healing in healthy and healing-impaired diabetic mice.European journal of immunology · 2020Article
- Sphingosine-1-Phosphate Facilitates Skin Wound Healing by Increasing Angiogenesis and Inflammatory Cell Recruitment with Less Scar Formation.International journal of molecular sciences · 2019Article
- A Disposable Photovoltaic Patch Controlling Cellular Microenvironment for Wound Healing.International journal of molecular sciences · 2018Article
- Creation of a Bioengineered Skin Flap Scaffold with a Perfusable Vascular Pedicle.Tissue engineering. Part A · 2017Article
- Macrophage interactions with polylactic acid and chitosan scaffolds lead to improved recruitment of human mesenchymal stem/stromal cells: a comprehensive study with different immune cells.Journal of the Royal Society, Interface · 2016Article
- Cutaneous tissue damage induces long-lasting nociceptive sensitization and regulation of cellular stress- and nerve injury-associated genes in sensory neurons.Experimental neurology · 2016Article
- NAP-2 Secreted by Human NK Cells Can Stimulate Mesenchymal Stem/Stromal Cell Recruitment.Stem cell reports · 2016Article
- Contribution of C-glucosidic ellagitannins to Lythrum salicaria L. influence on pro-inflammatory functions of human neutrophils.Journal of natural medicines · 2015Article
- Differential expression of granulocyte, macrophage, and hypoxia markers during early and late wound healing stages following transplantation of tissue-engineered skin substitutes of human origin.Pediatric surgery international · 2014Article
- Red blood cell lysate modulates the expression of extracellular matrix proteins in dermal fibroblasts.Molecular and cellular biochemistry · 2012Article
- Cell-mediated autophagy promotes cancer cell survival.Cancer research · 2012Article
- Enhanced mesenchymal stromal cell recruitment via natural killer cells by incorporation of inflammatory signals in biomaterials.Journal of the Royal Society, Interface · 2012Article
- Effects of hydrogen peroxide on wound healing in mice in relation to oxidative damage.PloS one · 2012Article
- The immune response to papillomavirus during infection persistence and regression.The open virology journal · 2012Article
- A novel role for NKT cells in cutaneous wound repair.The Journal of surgical research · 2011Article
- Systemic antitumor protection by vascular-targeted photodynamic therapy involves cellular and humoral immunity.Cancer immunology, immunotherapy : CII · 2009Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The process of wound healing begins with an inflammatory reaction that is principally dependent on cellular immune elements. Although the involvement in wound healing of leucocytes that mediate nonspecific immunity (e.g. neutrophils and macrophages) is well known, the participation of cells which prime the immune reaction, i.e. the lymphocytes, requires further investigation. This study was performed to examine the temporal sequence and kinetics of these cells during cutaneous wound repair. The model selected was a full-thickness skin excisional wound made on the flanks of female Wistar rats. At time points ranging from 3 h to 2 wk wound samples were processed for polyester wax-embedding. Target antigens were identified and monitored quantitatively in sections stained immunohistochemically. Monoclonal antibodies against neutrophils, macrophages, pan T cells and cytotoxic populations of lymphocytes were used. The results showed that these cells are involved in the process of wound healing in a distinctive dynamic pattern. The accumulation of CD3+ T lymphocytes in the wound bed was mainly associated with the phase of granulation tissue formation. Intraepithelial CD3+ T lymphocytes were detected in considerable numbers within the regenerating epidermis. The cytotoxic cell populations (OX8+) were classified morphologically into the cytotoxic/suppressor subset of T cells and NK cells. The OX8+ T cells were shown to have a kinetic pattern similar to CD3+ T lymphocytes but of a lower magnitude. The accumulation of OX8+ NK cells was confined to the early inflammatory phase of repair. It is concluded that CD3+ T lymphocytes as well as OX8+ cytotoxic populations of the immune system are involved in the process of cutaneous wound healing in temporal sequences which suggest that they may be involved in its modulation.
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Registered trials
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