SynthesisJournal of clinical laboratory analysis1999
Reference distributions for the negative acute-phase proteins, albumin, transferrin, and transthyretin: a comparison of a large cohort to the world's literature.
Synthesis in Journal of clinical laboratory analysis, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Reference distributions for apolipoproteins AI and B and B/AI ratios: comparison of a large cohort to the world's literature.Journal of clinical laboratory analysis · 2006Pooled it
- Reference distributions for complement proteins C3 and C4: a comparison of a large cohort to the world's literature.Journal of clinical laboratory analysis · 2004Pooled it
- Reference distributions for serum iron and transferrin saturation: a comparison of a large cohort to the world's literature.Journal of clinical laboratory analysis · 2002Pooled it
- Reference distributions for the positive acute phase proteins, alpha1-acid glycoprotein (orosomucoid), alpha1-antitrypsin, and haptoglobin: a comparison of a large cohort to the world's literature.Journal of clinical laboratory analysis · 2000Pooled it
- Remodeling of the HDL proteome with treatment response to abatacept or adalimumab in the AMPLE trial of patients with rheumatoid arthritis.Atherosclerosis · 2018Trial
- Serum transferrin as a potential marker for prediction of prognosis for sudden sensorineural hearing loss: a prospective study.BMC neurology · 2025Article
- Dystocia in the Standardbred Mare: A Retrospective Study from 2004 to 2020.Animals : an open access journal from MDPI · 2022Article
- Serum transferrin as a biomarker of hepatocyte nuclear factor 4 alpha activity and hepatocyte function in liver diseases.BMC medicine · 2021Article
- Serum Transferrin Is an Independent Predictor of Mortality in Severe Alcoholic Hepatitis.The American journal of gastroenterology · 2020Article
- Cerebrospinal fluid (CSF) biomarkers of iron status are associated with CSF viral load, antiretroviral therapy, and demographic factors in HIV-infected adults.Fluids and barriers of the CNS · 2017Observational
- Inflammation, Glutamate, and Glia: A Trio of Trouble in Mood Disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Review
- The impact of growth hormone on proteomic profiles: a review of mouse and adult human studies.Clinical proteomics · 2017Review
- Beyond the joints in rheumatoid arthritis: Effects of adalimumab on hematologic and lipid indices.EXCLI journal · 2012Article
- Potential biomarkers in the sera of breast cancer patients from bahawalpur, pakistan.Biomarkers in cancer · 2012Article
- Friend of GATA suppresses the GATA-induced transcription of hepcidin in hepatocytes through a GATA-regulatory element in the HAMP promoter.Journal of molecular endocrinology · 2011Article
- Plasma biomarkers of mouse aging.Age (Dordrecht, Netherlands) · 2011Article
- Co-culture of primary rat hepatocytes with rat liver epithelial cells enhances interleukin-6-induced acute-phase protein response.Cell and tissue research · 2010Article
- Risk of zinc, iodine and other micronutrient deficiencies among school children in North East Thailand.European journal of clinical nutrition · 2006Article
- Reference distributions for alpha2-macroglobulin: a comparison of a large cohort to the world's literature.Journal of clinical laboratory analysis · 2004Review
- Reference distributions for the negative acute-phase serum proteins, albumin, transferrin and transthyretin: a practical, simple and clinically relevant approach in a large cohort.Journal of clinical laboratory analysis · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clinical interpretation of the acute-phase proteins--albumin, transferrin, and transthyretin--has been hampered by the lack of accurate and precise methods for quantifying the levels and a stable and respected reference material. Now that these issues have been addressed, the community is faced with the need for credible age- and gender-specific reference values. The number of publications that address this issue, even for an analyte as familiar as albumin, is small and, in most cases, such publications lack the relevant data that would allow a combined experience to be created. We have identified 40 studies that meet our criteria: a description of the study participants' health status, of the statistical methodology, and of the laboratory technique and/or reference material used. Few of these studies reported values stratified by gender. A summary of the published median levels by age is presented for the three analytes, along with our own age- and gender-specific medians based on a large cohort. Ten of the studies presented a 95 percent reference range, in close agreement with ours where selection was based upon reported diagnosis rather than upon determination of individual health status. This meta-analysis provides support for the reliability of our recently published methodology and reference data for the clinical interpretation of individual albumin, transferrin, and transthyretin values. As with most laboratory measurements, clinical interpretation requires that other laboratory and clinical factors be considered.
Indexed as
Identifiers
10633295PMC6807761W2082798128What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.