Evidence map›Paper›PMID 10633124›Full record

ArticleJournal of bacteriology2000

Sequence variations within PrfA DNA binding sites and effects on Listeria monocytogenes virulence gene expression.

J R Williams, C Thayyullathil, N E Freitag

Abstract read
In one paragraph

Article in Journal of bacteriology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

J R WilliamsDepartment of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan.
C Thayyullathil
N E Freitag

Funding

Listeria Virulence Gene Expression Within Host CellsR01AI041816 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI FREITAG, NANCY ELIZABETH · 2001 to 2010
$3.9M
Listeria virulence gene expression within host cellsR56AI041816 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI FREITAG, NANCY ELIZABETH · 2012 to 2012
$399k
LISTERIA VIRULENCE GENE EXPRESSION WITHIN HOST CELLSR29AI041816 · NIAID · WAYNE STATE UNIVERSITY · PI FREITAG, NANCY · 1997 to 2001
$253k
NIAID NIH HHS AI41816NIAID NIH HHS R01 AI041816NIAID NIH HHS R29 AI041816NIAID NIH HHS R56 AI041816
6 · The paper itself

Abstract

Reporter gene fusions were used to investigate the contributions of PrfA DNA binding sites to Listeria monocytogenes virulence gene expression. Our results suggest that the DNA sequence of PrfA binding sites determines the levels of expression of certain virulence genes, such as hly and mpl. Other virulence genes, such as actA and plcB, may depend upon additional factors for full regulation of gene expression.

Indexed as

Gene Expression Regulation, BacterialBacterial ProteinsBinding SitesDNA, BacterialListeria monocytogenesMembrane ProteinsMetalloendopeptidasesMutationPeptide Termination FactorsPromoter Regions, GeneticSequence Analysis, DNATrans-ActivatorsactA protein, Listeria monocytogenesBacterial ProteinsDNA, BacterialMembrane ProteinsMetalloendopeptidasesmpl protein, Listeria monocytogenesPeptide Termination FactorsTrans-Activators

Identifiers

PMID10633124
PMCPMC94353

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.