ArticleJournal of bacteriology2000
Increased sensitivity to oxidative challenges associated with topA deletion in Escherichia coli.
Article in Journal of bacteriology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Bacterial Topoisomerase I Growth Complementation Assay.Methods in molecular biology (Clifton, N.J.) · 2025Article
- An integrated proteo-transcriptomics approach reveals novel drug targets against multidrug resistantFrontiers in microbiology · 2025Article
- Insights into the Lysine Acetylome of the HaloarchaeonAntioxidants (Basel, Switzerland) · 2023Article
- Regulatory Effect of DNA Topoisomerase I on T3SS Activity, Antibiotic Susceptibility and Quorum- Sensing-Independent Pyocyanin Synthesis inInternational journal of molecular sciences · 2019Article
- Biochemical Basis ofInternational journal of molecular sciences · 2018Article
- Deacetylation of topoisomerase I is an important physiological function of E. coli CobB.Nucleic acids research · 2017Article
- The Coordinated Positive Regulation of Topoisomerase Genes Maintains Topological Homeostasis in Streptomyces coelicolor.Journal of bacteriology · 2016Article
- Antimicrobial Susceptibility and SOS-Dependent Increase in Mutation Frequency Are Impacted by Escherichia coli Topoisomerase I C-Terminal Point Mutation.Antimicrobial agents and chemotherapy · 2015Article
- Targeting bacterial topoisomerase I to meet the challenge of finding new antibiotics.Future medicinal chemistry · 2015Review
- Iron inhibits Escherichia coli topoisomerase I activity by targeting the first two zinc-binding sites in the C-terminal domain.Protein science : a publication of the Protein Society · 2014Article
- Escherichia coli topoisomerase I is an iron and zinc binding protein.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2011Article
- Topoisomerase I function during Escherichia coli response to antibiotics and stress enhances cell killing from stabilization of its cleavage complex.The Journal of antimicrobial chemotherapy · 2011Article
- Hydroxyl radicals are involved in cell killing by the bacterial topoisomerase I cleavage complex.Journal of bacteriology · 2009Article
- Bacterial topoisomerase I as a target for discovery of antibacterial compounds.Nucleic acids research · 2009Review
- SOS induction by stabilized topoisomerase IA cleavage complex occurs via the RecBCD pathway.Journal of bacteriology · 2008Article
- Distribution of gyrase and topoisomerase IV on bacterial nucleoid: implications for nucleoid organization.Nucleic acids research · 2006Article
- Bacterial cell killing mediated by topoisomerase I DNA cleavage activity.The Journal of biological chemistry · 2005Article
- Loss of topoisomerase I function affects the RpoS-dependent and GAD systems of acid resistance in Escherichia coli.Microbiology (Reading, England) · 2005Article
- Identification of pathogen-specific and conserved genes expressed in vivo by an avian pathogenic Escherichia coli strain.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Deletion of topA in Escherichia coli was found to result in a higher level of killing after treatment with either hydrogen peroxide or N-ethylmaleimide. This effect on oxidative challenge response represents a new role for E. coli DNA topoisomerase I in addition to prevention of excessive negative supercoiling of DNA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.