Evidence map›Paper›PMID 10632610›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000

GABA(C) receptors control adaptive changes in a glycinergic inhibitory pathway in salamander retina.

P B Cook, P D Lukasiewicz, J S McReynolds

Open access · bronzeAbstract read

In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it

0cells of the map it votes in

10citing papers in PubMed

0.8field-weighted citation impact, top 33% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

Adaptation of Inhibition Mediates Retinal Sensitization.Current biology : CB · 2019
Article
GABAergic neurotransmission and retinal ganglion cell function.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2015
Review
The retinal hypercircuit: a repeating synaptic interactive motif underlying visual function.The Journal of physiology · 2011
Review
GABA(B) receptor feedback regulation of bipolar cell transmitter release.The Journal of physiology · 2010
Article
Whole-cell recordings of light evoked excitatory synaptic currents in the retinal slice.Journal of visualized experiments : JoVE · 2008
Article
Long-term plasticity mediated by mGluR1 at a retinal reciprocal synapse.Neuron · 2005
Article
Nitric oxide stimulates gamma-aminobutyric acid release and inhibits glycine release in retina.The Journal of comparative neurology · 2005
Article
The classical receptive field surround of primate parasol ganglion cells is mediated primarily by a non-GABAergic pathway.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004
Article
Elimination of the rho1 subunit abolishes GABA(C) receptor expression and alters visual processing in the mouse retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002
Article
Temporal contrast adaptation in salamander bipolar cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

P B CookDepartment of Physiology, The University of Michigan, Ann Arbor, Michigan 48109-0622, USA. pcook@umich.edu

P D Lukasiewicz

J S McReynolds

University of Michigan–Ann Arbor · USWashington University in St. Louis · US

Funding

Synaptic transmission &its modulation in the retinaR01EY008922 · NEI · WASHINGTON UNIVERSITY · PI LUKASIEWICZ, PETER D · 1991 to 2017

$7.2M

FUNCTIONAL ORGANIZATION OF THE RETINAR01EY001653 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MC REYNOLDS, JOHN S · 1985 to 2002

$751k

NEI NIH HHS EY01653NEI NIH HHS EY07003NEI NIH HHS EY08922

6 · The paper itself

Abstract

We studied the role of GABA in adaptive changes in a lateral inhibitory system in the tiger salamander retina. In dark-adapted retinal slice preparations picrotoxin caused a slow enhancement of glycine-mediated IPSCs in ganglion cells. The enhancement of glycinergic IPSCs developed slowly over the course of 5-20 min, even though picrotoxin blocked both GABA(A) and GABA(C) receptors within a few seconds. The slow enhancement of glycinergic IPSCs by picrotoxin was much weaker in light-adapted preparations. The slow enhancement of glycinergic inhibitory inputs was not produced by bicuculline, indicating that it involved GABA(C) receptors. The responses of ganglion cells to direct application of glycine were not enhanced by picrotoxin, indicating that the enhancement was not caused by an action on glycine receptors. In dark-adapted eyecup preparations picrotoxin caused a slow enhancement of glycinergic IPSPs and transient lateral inhibition produced by a rotating windmill pattern, similar to the effect of light adaptation. The results suggest that the glycinergic inhibitory inputs are modulated by an unknown substance whose synthesis and/or release is inhibited in dark-adapted retinas by GABA acting at GABA(C) receptors.

Indexed as

Adaptation, OcularAmbystomaAnimalsDarknessEvoked PotentialsGlycineIn Vitro TechniquesKineticsLarvaPatch-Clamp TechniquesPicrotoxinReaction TimeReceptors, GABARetinaRetinal Ganglion CellsGABA-C receptorGlycinePicrotoxinReceptors, GABA

Identifiers

PMID10632610

PMCPMC6772420

OpenAlexW2125283446

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.