ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
Novel mechanism of massive photoreceptor degeneration caused by mutations in the trp gene of Drosophila.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 103 citations in OpenAlex.
- Cold-Sensing TRP Channels and Temperature Preference Modulate Ovarian Development in the Model OrganismInternational journal of molecular sciences · 2025Article
- Diacylglycerol Activates theInternational journal of molecular sciences · 2023Article
- Increase in membrane surface expression and phosphorylation of TRPC3 related to olfactory dysfunction in α-synuclein transgenic mice.Journal of cellular and molecular medicine · 2022Article
- Dietary restriction and the transcription factor clock delay eye aging to extend lifespan in Drosophila Melanogaster.Nature communications · 2022Article
- Article
- Trypanocidal Essential Oils: A Review.Molecules (Basel, Switzerland) · 2020Review
- Human eye conditions: insights from the fly eye.Human genetics · 2019Review
- A Single Residue Mutation in the GαG3 (Bethesda, Md.) · 2018Article
- Cytochrome b5 protects photoreceptors from light stress-induced lipid peroxidation and retinal degeneration.NPJ aging and mechanisms of disease · 2017Article
- PINK1 and Parkin cooperatively protect neurons against constitutively active TRP channel-induced retinal degeneration in Drosophila.Cell death & disease · 2016Article
- Ocular transient receptor potential channel function in health and disease.BMC ophthalmology · 2015Review
- The GTP- and Phospholipid-Binding Protein TTD14 Regulates Trafficking of the TRPL Ion Channel in Drosophila Photoreceptor Cells.PLoS genetics · 2015Article
- Impaired Mitochondrial Energy Production Causes Light-Induced Photoreceptor Degeneration Independent of Oxidative Stress.PLoS biology · 2015Article
- A new genetic model for calcium induced autophagy and ER-stress in Drosophila photoreceptor cells.Channels (Austin, Tex.) · 2015Article
- Article
- Progressive degeneration of dopaminergic neurons through TRP channel-induced cell death.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Article
- Compartmentalization and Ca2+ buffering are essential for prevention of light-induced retinal degeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Increased basal activity is a key determinant in the severity of human skeletal dysplasia caused by TRPV4 mutations.PloS one · 2011Article
- The history of the Drosophila TRP channel: the birth of a new channel superfamily.Journal of neurogenetics · 2010Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
The Drosophila trp gene encodes a light-activated Ca(2+) channel subunit, which is a prototypical member of a novel class of channel proteins. Previously identified trp mutants are all recessive, loss-of-function mutants characterized by a transient receptor potential and the total or near-total loss of functional TRP protein. Although retinal degeneration does occur in these mutants, it is relatively mild and slow in onset. We report herein a new mutant, Trp(P365), that does not display the transient receptor potential phenotype and is characterized by a substantial level of the TRP protein and rapid, semi-dominant degeneration of photoreceptors. We show that, in spite of its unusual phenotypes, Trp(P365) is a trp allele because a Trp(P365) transgene induces the mutant phenotype in a wild-type background, and a wild-type trp transgene in a Trp(P365) background suppresses the mutant phenotype. Moreover, amino acid alterations that could cause the Trp(P365) phenotype are found in the transmembrane segment region of the mutant channel protein. Whole-cell recordings clarified the mechanism underlying the retinal degeneration by showing that the TRP channels of Trp(P365) are constitutively active. Although several genes, when mutated, have been shown to cause retinal degeneration in Drosophila, the underlying mechanism has not been identified for any of them. The present studies provide evidence for a specific mechanism for massive degeneration of photoreceptors in Drosophila. Insofar as some human homologs of TRP are highly expressed in the brain, a similar mechanism could be a major contributor to degenerative disorders of the brain.
Indexed as
Identifiers
10632594PMC6772429W2170991485What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.