ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
Synaptic depression and the kinetics of exocytosis in retinal bipolar cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed, 103 citations in OpenAlex.
- Article
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- Filter-based models of suppression in retinal ganglion cells: Comparison and generalization across species and stimuli.PLoS computational biology · 2025Article
- Temporal pattern recognition in retinal ganglion cells is mediated by dynamical inhibitory synapses.Nature communications · 2024Article
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- Tandem pore domain acid-sensitive K channel 3 (TASK-3) regulates visual sensitivity in healthy and aging retina.Science advances · 2022Article
- Rapid propagation of membrane tension at retinal bipolar neuron presynaptic terminals.Science advances · 2022Article
- A theoretical model reveals specialized synaptic depressions and temporal frequency tuning in retinal parallel channels.Frontiers in computational neuroscience · 2022Article
- Direct Observation of Vesicle Transport on the Synaptic Ribbon Provides Evidence That Vesicles Are Mobilized and Prepared Rapidly for Release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- An amplitude code transmits information at a visual synapse.Nature neuroscience · 2019Article
- The Transfer Characteristics of Hair Cells Encoding Mechanical Stimuli in the Lateral Line of Zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Adaptive feature detection from differential processing in parallel retinal pathways.PLoS computational biology · 2018Article
- Diversity in spatial scope of contrast adaptation among mouse retinal ganglion cells.Journal of neurophysiology · 2017Article
- General features of inhibition in the inner retina.The Journal of physiology · 2017Review
- Article
- Neural Circuit Inference from Function to Structure.Current biology : CB · 2017Article
- Nonlinear Spatiotemporal Integration by Electrical and Chemical Synapses in the Retina.Neuron · 2016Article
- Glutamatergic Retinal Waves.Frontiers in neural circuits · 2016Review
- Calcium spike-mediated digital signaling increases glutamate output at the visual threshold of retinal bipolar cells.Journal of neurophysiology · 2015Article
- The neural circuit mechanisms underlying the retinal response to motion reversal.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The capacitance technique was used to investigate exocytosis at the ribbon synapse of depolarizing bipolar cells from the goldfish retina. When the Ca(2+) current was activated strongly, the rapidly releasable pool of vesicles (RRP) was released with a single rate-constant of approximately 300-500 sec(-1). However, when the Ca(2+) current was activated weakly by depolarization in the physiological range (-45 to -25 mV), exocytosis from the RRP occurred in two phases. After the release of 20% or more of the RRP, the rate-constant of exocytosis fell by a factor of 4-10. Thus, synaptic depression was caused by a reduced sensitivity to Ca(2+) influx, as well as simple depletion of the RRP. In the resting state, the rate of exocytosis varied with the amplitude of the Ca(2+) current raised to the power of 2. In the depressed state, the sensitivity to Ca(2+) influx was reduced approximately fourfold. The initial phase of exocytosis accelerated e-fold for every 2.1 mV depolarization over the physiological range and averaged 120 sec(-1) at -25 mV. The synapse of depolarizing bipolar cells therefore responds to a step depolarization in a manner similar to a high-pass filter. This transformation appears to be determined by the presence of rapidly releasable vesicles with differing sensitivities to Ca(2+) influx. This might occur if vesicles were docked to the plasma membrane at different distances from Ca(2+) channels. These results suggest that the ribbon synapse of depolarizing bipolar cells may be a site of adaptation in the retina.
Indexed as
Identifiers
10632586PMC6772421W1955574248What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.