ArticleAmerican journal of human genetics2000
Full-genome scan for linkage in 50 families segregating the bipolar affective disease phenotype.
Article in American journal of human genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Exome Sequencing of Familial Bipolar Disorder.JAMA psychiatry · 2016Pooled it
- Pooled it
- Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia.Molecular psychiatry · 2002Pooled it
- Family History in Patients with Bipolar Disorder.Noro psikiyatri arsivi · 2016Article
- Chromosome 18p11.2 harbors susceptibility marker: D18S452, for bipolar affective disorder.Indian journal of psychiatry · 2013Article
- A review of potassium channels in bipolar disorder.Frontiers in genetics · 2013Article
- The genetics of bipolar disorder: genome 'hot regions,' genes, new potential candidates and future directions.Molecular psychiatry · 2008Review
- Genetic variation of the FAT gene at 4q35 is associated with bipolar affective disorder.Molecular psychiatry · 2008Article
- Positional cloning, association analysis and expression studies provide convergent evidence that the cadherin gene FAT contains a bipolar disorder susceptibility allele.Molecular psychiatry · 2006Article
- Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q.American journal of human genetics · 2005Article
- Linkage of bipolar affective disorder on chromosome 8q24: follow-up and parametric analysis.Molecular psychiatry · 2004Article
- Linkage of a bipolar disorder susceptibility locus to human chromosome 13q32 in a new pedigree series.Molecular psychiatry · 2003Article
- Genome-wide scan of bipolar disorder in 65 pedigrees: supportive evidence for linkage at 8q24, 18q22, 4q32, 2p12, and 13q12.Molecular psychiatry · 2003Article
- Evidence for a putative bipolar disorder locus on 2p13-16 and other potential loci on 4q31, 7q34, 8q13, 9q31, 10q21-24, 13q32, 14q21 and 17q11-12.Molecular psychiatry · 2003Article
- Manic-depression genes and the new millennium: poised for discovery.Molecular psychiatry · 2002Review
- Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor.Molecular psychiatry · 2002Article
- A genome screen of 13 bipolar affective disorder pedigrees provides evidence for susceptibility loci on chromosome 3 as well as chromosomes 9, 13 and 19.Molecular psychiatry · 2002Article
- A genome-wide scan shows significant linkage between bipolar disorder and chromosome 12q24.3 and suggestive linkage to chromosomes 1p22-21, 4p16, 6q14-22, 10q26 and 16p13.3.Molecular psychiatry · 2002Article
- Novel polymorphisms in the somatostatin receptor 5 (SSTR5) gene associated with bipolar affective disorder.Molecular psychiatry · 2002Article
- A genome screen of 13 bipolar affective disorder pedigrees provides evidence for susceptibility loci on chromosome 3 as well as chromosomes 9, 13 and 19.Molecular psychiatry · 2002Article
Corrections and comments
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Authors and funding
21 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A genome scan of approximately 12-cM initial resolution was done on 50 of a set of 51 carefully ascertained unilineal multiplex families segregating the bipolar affective disorder phenotype. In addition to standard multipoint linkage analysis methods, a simultaneous-search algorithm was applied in an attempt to surmount the problem of genetic heterogeneity. The results revealed no linkage across the genome. The results exclude monogenic models and make it unlikely that two genes account for the disease in this sample. These results support the conclusion that at least several hundred kindreds will be required in order to establish linkage of susceptibility loci to bipolar disorder in heterogeneous populations.
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