Evidence map›Paper›PMID 10630644›Full record

ReviewOncogene1999

Growth factor signaling pathways in vascular development.

M D Tallquist, P Soriano, R A Klinghoffer

Abstract readReview
PubMed Publisher
In one paragraph

Review in Oncogene, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 102 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Advanced research on vasculogenic mimicry in cancer.Journal of cellular and molecular medicine · 2015
    Review
  8. Cardiac outflow tract anomalies.Wiley interdisciplinary reviews. Developmental biology · 2013
    Review
  9. Article
  10. Cardiomyopathy in the mouse model of Duchenne muscular dystrophy caused by disordered secretion of vascular endothelial growth factor.Medical science monitor : international medical journal of experimental and clinical research · 2011
    Article
  11. Article
  12. Article
  13. Article
  14. Novel aspects of corneal angiogenic and lymphangiogenic privilege.Progress in retinal and eye research · 2010
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

M D TallquistDivision of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
P Soriano
R A Klinghoffer
Fred Hutch Cancer Center · US

Funding

SIGNAL TRANSDUCTION AND MOUSE DEVELOPMENTR37HD025326 · NICHD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SORIANO, PHILIPPE M · 2001 to 2010
$4.9M
RETROVIRUSES AS PROBES FOR DEVELOPMENTR01HD024875 · NICHD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SORIANO, PHILIPPE M · 1989 to 2010
$4.5M
INSERTIONAL MUTAGENESIS AND MOUSE DEVELOPMENTR01HD025326 · NICHD · FRED HUTCHINSON CANCER RESEARCH CENTER · PI SORIANO, PHILIPPE M · 1989 to 1999
–
NICHD NIH HHS HD08412NICHD NIH HHS HD24875NICHD NIH HHS HD25326
6 · The paper itself

Abstract

Recent research on the formation and maintenance of the vasculature in the embryo and in the adult has provided a greater understanding of the cellular signals involved in these processes. With this understanding comes the potential means of controlling vascularization in pathological situations such as tumorigenesis and wounding. For the purpose of this review, we will discuss the key receptor tyrosine kinases involved in vascular function and the molecules which relay signals downstream of receptor activation. The receptor tyrosine kinases discussed include the vascular endothelial cell growth factor receptors, Eph receptors, Tie1, and Tie2, all of which are expressed on vascular endothelial cells. We also discuss the roles of the platelet derived growth factor receptors which are expressed on vascular smooth muscle cells. While all of these receptor tyrosine kinases activate many similar effector molecules, some of the signals initiated appear to be distinct. This may explain, at least in part, how different receptor tyrosine kinases expressed in overlapping patterns on the developing vasculature, direct unique biological functions.

Indexed as

Neovascularization, PhysiologicAgingAnimalsEmbryonic and Fetal DevelopmentEndothelium, VascularGrowth SubstancesHumansReceptor Protein-Tyrosine KinasesReceptors, Growth FactorReceptors, TIEReceptors, Vascular Endothelial Growth FactorReceptor, TIE-1Signal TransductionGrowth SubstancesReceptor Protein-Tyrosine KinasesReceptors, Growth FactorReceptors, TIEReceptors, Vascular Endothelial Growth FactorReceptor, TIE-1

Identifiers

PMID10630644
OpenAlexW2323585944

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.