ArticleMolecular and cellular biochemistry1999
Enhanced chemotaxis of macrophages by strenuous exercise in trained mice: thyroid hormones as possible mediators.
Article in Molecular and cellular biochemistry, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 22 citations in OpenAlex.
- Research Advancements in the Interplay between T3 and Macrophages.Current medical science · 2024Review
- Hashimoto's thyroiditis increases the risk of new-onset systemic lupus erythematosus: a nationwide population-based cohort study.Arthritis research & therapy · 2023Article
- Liver macrophages and inflammation in physiology and physiopathology of non-alcoholic fatty liver disease.The FEBS journal · 2022Review
- Hormones and immunity in cancer: are thyroid hormones endocrine players in the microglia/glioma cross-talk?Frontiers in cellular neuroscience · 2015Article
- Exercise Induced Alterations in Rat Monocyte Number, Morphology, and Function.International journal of exercise scienceArticle
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exercise modulates the macrophage activity via 'stress hormones'. Three experiments were performed. (1) The effect of strenuous exercise performed by trained mice on macrophage chemotactic capacity was evaluated; (2) peritoneal macrophages from control mice were incubated with plasma from exercised mice or control mice and the differences in chemotaxis were measured; (3) changes in plasma T3 and T4 levels after exercise were measured, and the effect of incubation with the post-exercise levels of plasma T3 and T4 on chemotaxis was then studied in vitro. A 10(4)-fold higher concentration of each hormone was also evaluated. Exercise provoked an increase in chemotaxis (104 +/- 35 vs. 47 +/- 11 in controls). Incubation with plasma from exercised mice led to an increased level of chemotaxis. Incubation with concentrations of T3 and T4 similar to those observed in post-exercise plasma (T3, 2.3 nmol l(-1); T4, 84 nmol l(-1)) enhanced chemotaxis with respect to incubation with the basal concentrations of the hormones in control animals. A 10(4)-fold concentration of T4 reversed this effect. It is concluded that thyroid hormones stimulate macrophage chemotaxis. Also, these data support the hypothesis that thyroid hormones may be involved in exercise-induced stimulation of chemotaxis.
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Registered trials
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