ArticleDigestive diseases and sciences1999
Experimental colitis induced by trinitrobenzenesulfonic acid: an ultrastructural and histochemical study.
Article in Digestive diseases and sciences, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 49 citations in OpenAlex.
- Beneficial effect of butyrate, Lactobacillus casei and L-carnitine combination in preference to each in experimental colitis.World journal of gastroenterology · 2014Article
- Myroides pelagicus from the gut of Drosophila melanogaster attenuates inflammation on dextran sodium sulfate-induced colitis.Digestive diseases and sciences · 2014Article
- Effects of Carum carvi L. (Caraway) extract and essential oil on TNBS-induced colitis in rats.Research in pharmaceutical sciences · 2013Article
- Use of propolis hydroalcoholic extract to treat colitis experimentally induced in rats by 2,4,6-trinitrobenzenesulfonic Acid.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Preventive Therapy of Experimental Colitis with Selected iron Chelators and Anti-oxidants.International journal of preventive medicine · 2012Article
- Isolation and Characterization of Putative Probiotic Bacterial Strain, Bacillus amyloliquefaciens, from North East Himalayan Soil Based on In Vitro and In Vivo Functional Properties.Probiotics and antimicrobial proteins · 2011Article
- Effects of extract and essential oil of Rosmarinus officinalis L. on TNBS-induced colitis in rats.Research in pharmaceutical sciences · 2011Article
- Proinflammatory and anti-inflammatory cytokines present in the acute phase of experimental colitis treated with Saccharomyces boulardii.Digestive diseases and sciences · 2010Article
- Current view of the immunopathogenesis in inflammatory bowel disease and its implications for therapy.World journal of gastroenterology · 2008Review
- Attenuation of inflammation and cytokine production in rat colitis by a novel selective inhibitor of leukotriene A4 hydrolase.British journal of pharmacology · 2008Article
- The effects of resveratrol, a phytoalexin derived from red wines, on chronic inflammation induced in an experimentally induced colitis model.British journal of pharmacology · 2006Article
- Structural and neuronal changes in rat ileum after ischemia with reperfusion.Digestive diseases and sciences · 2004Article
- Porcine ileitis model induced by TNBS-ethanol instillation.Digestive diseases and sciences · 2002Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammatory bowel disease (IBD) of humans is a chronic and devastating disease of unknown etiology. Models of acute colitis in animals have been achieved by intrarectal administration of agents such as 2,4,6-trinitrobenzenesulfonic acid (TNBS) into rat colon. This agent induces focal inflammation and alterations in the colon with features similar to those found in chronic inflammatory diseases in humans. The aim of this study was to assess the effect of TNBS administration on histological and ultrastructural features of the rat colon, especially in areas not affected by transmural inflammation. Also in areas without transmural inflammation, we observed a significant increase in crypt diameter and in the number and area of the goblet cells, as well as alterations in the contents of mucin in goblet cells. We conclude that TNBS treatment in rats led to severe changes in normal architecture of the colon and also in damaged areas where no direct inflammation was produced.
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