Evidence map›Paper›PMID 10629205›Full record

ArticleJournal of bacteriology2000

Overexpression of the RNA polymerase alpha subunit reduces transcription of Bvg-activated virulence genes in Bordetella pertussis.

N H Carbonetti, A Romashko, T J Irish

Abstract read
In one paragraph

Article in Journal of bacteriology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

N H CarbonettiDepartment of Microbiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA. ncarbone@umaryland.edu
A Romashko
T J Irish

Funding

BORDETELLA PERTUSSIS VIRULENCE FACTOR GENE REGULATIONR29AI032946 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI CARBONETTI, NICHOLAS H. · 1992 to 1996
–
NIAID NIH HHS AI32946
6 · The paper itself

Abstract

Overexpression of the RNA polymerase alpha subunit in Bordetella pertussis reduces expression of the virulence factor pertussis toxin. Here we show that this reduction is at the level of transcription, is reversed by overexpression of the transcriptional activator BvgA, and is dependent on the C-terminal domain of alpha.

Indexed as

Escherichia coli ProteinsTranscription, GeneticBacterial ProteinsBordetella pertussisDNA-Directed RNA PolymerasesEscherichia coliStructure-Activity RelationshipTranscription FactorsBacterial ProteinsBvgA protein, BacteriaDNA-Directed RNA PolymerasesEscherichia coli ProteinsEvgA protein, E coliRNA polymerase alpha subunitTranscription Factors

Identifiers

PMID10629205
PMCPMC94308

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.