ArticleMolecular and cellular biology2000
Cdc37 promotes the stability of protein kinases Cdc28 and Cak1.
Article in Molecular and cellular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 55 citations in OpenAlex.
- Cdc37 facilitates cell survival of colorectal carcinoma via activating the CDK4 signaling pathway.Cancer science · 2018Article
- Phosphoproteome dynamics of Saccharomyces cerevisiae under heat shock and cold stress.Molecular systems biology · 2015Article
- Restricting direct interaction of CDC37 with HSP90 does not compromise chaperoning of client proteins.Oncogene · 2015Article
- Article
- Cdc37 engages in stable, S14A mutation-reinforced association with the most atypical member of the yeast kinome, Cdk-activating kinase (Cak1).Cell stress & chaperones · 2014Article
- Functions of the Hsp90 chaperone system: lifting client proteins to new heights.International journal of biochemistry and molecular biology · 2013Review
- ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system.Nature chemical biology · 2013Article
- Behind the curtain: cellular mechanisms for allosteric modulation of calcium-sensing receptors.British journal of pharmacology · 2012Review
- Ydj1 protects nascent protein kinases from degradation and controls the rate of their maturation.Molecular and cellular biology · 2008Article
- The Hsp110 protein chaperone Sse1 is required for yeast cell wall integrity and morphogenesis.Current genetics · 2008Article
- Alteration of the protein kinase binding domain enhances function of the Saccharomyces cerevisiae molecular chaperone Cdc37.Eukaryotic cell · 2007Article
- The Schizosaccharomyces pombe Cdc7 protein kinase required for septum formation is a client protein of Cdc37.Eukaryotic cell · 2007Article
- Mechanisms regulating the protein kinases of Saccharomyces cerevisiae.Eukaryotic cell · 2007Review
- Cdc37p is required for stress-induced high-osmolarity glycerol and protein kinase C mitogen-activated protein kinase pathway functionality by interaction with Hog1p and Slt2p (Mpk1p).Eukaryotic cell · 2007Article
- Cdc37 has distinct roles in protein kinase quality control that protect nascent chains from degradation and promote posttranslational maturation.The Journal of cell biology · 2007Article
- Cdc37 interacts with the glycine-rich loop of Hsp90 client kinases.Molecular and cellular biology · 2006Article
- Discovery of biological networks from diverse functional genomic data.Genome biology · 2005Article
- CK2 controls multiple protein kinases by phosphorylating a kinase-targeting molecular chaperone, Cdc37.Molecular and cellular biology · 2004Article
- Fission yeast Cdc37 is required for multiple cell cycle functions.Molecular genetics and genomics : MGG · 2004Article
- Identification of Cdc37 as a novel regulator of the stress-responsive mitogen-activated protein kinase.Molecular and cellular biology · 2003Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the budding yeast Saccharomyces cerevisiae, Cdc37 is required for the productive formation of Cdc28-cyclin complexes. The cdc37-1 mutant arrests at Start with low levels of Cdc28 protein, which is predominantly unphosphorylated at Thr169, fails to bind cyclin, and has little protein kinase activity. We show here that Cdc28 and not cyclin is specifically defective in the cdc37-1 mutant and that Cdc37 likely does not act as an assembly factor for Cdc28-cyclin complex formation. We have also found that the levels and activity of the protein kinase Cak1 are significantly reduced in the cdc37-1 mutant. Pulse-chase analysis indicates that Cdc28 and Cak1 proteins are both destabilized when Cdc37 function is absent during but not after translation. In addition, Cdc37 promotes the production of Cak1, but not that of Cdc28, when coexpressed in insect cells. We conclude that budding yeast Cdc37, like its higher eukaryotic homologs, promotes the physical integrity of multiple protein kinases, perhaps by virtue of a cotranslational role in protein folding.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.