ArticleGenetics2000
Cellular Werner phenotypes in mice expressing a putative dominant-negative human WRN gene.
Article in Genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 62 citations in OpenAlex.
- Deficiency of Werner RecQ-type DNA helicase causes premature malnutrition in zebrafish.iScience · 2026Article
- Response to Replication Stress and Maintenance of Genome Stability by WRN, the Werner Syndrome Protein.International journal of molecular sciences · 2024Review
- RecQ dysfunction contributes to social and depressive-like behavior and affects aldolase activity in mice.Neurobiology of disease · 2023Article
- WRN is recruited to damaged telomeres via its RQC domain and tankyrase1-mediated poly-ADP-ribosylation of TRF1.Nucleic acids research · 2017Article
- WRN Mutation Update: Mutation Spectrum, Patient Registries, and Translational Prospects.Human mutation · 2017Review
- Genetic Manipulation of Homologous Recombination In Vivo Attenuates Intestinal Tumorigenesis.Cancer prevention research (Philadelphia, Pa.) · 2015Article
- Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice.PloS one · 2015Article
- Liver aging and pseudocapillarization in a Werner syndrome mouse model.The journals of gerontology. Series A, Biological sciences and medical sciences · 2014Article
- Article
- Helicase-inactivating mutations as a basis for dominant negative phenotypes.Cell cycle (Georgetown, Tex.) · 2010Review
- Shortcomings of short hairpin RNA-based transgenic RNA interference in mouse oocytes.Journal of negative results in biomedicine · 2010Article
- Divergent cellular phenotypes of human and mouse cells lacking the Werner syndrome RecQ helicase.DNA repair · 2010Article
- RecQ DNA helicase HRDC domains are critical determinants in Neisseria gonorrhoeae pilin antigenic variation and DNA repair.Molecular microbiology · 2009Article
- From old organisms to new molecules: integrative biology and therapeutic targets in accelerated human ageing.Cellular and molecular life sciences : CMLS · 2007Review
- Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair.Neuroscience · 2007Review
- Sit down, relax and unwind: structural insights into RecQ helicase mechanisms.Nucleic acids research · 2006Review
- Telomere instability in a human tumor cell line expressing a dominant-negative WRN protein.Human genetics · 2003Article
- Werner Syndrome.Journal of biomedicine & biotechnology · 2002Article
- Article
- Transgenic animals as models for human disease.Transgenic research · 2000Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Mutations at the Werner helicase locus (WRN) are responsible for the Werner syndrome (WS). WS patients prematurely develop an aged appearance and various age-related disorders. We have generated transgenic mice expressing human WRN with a putative dominant-negative mutation (K577M-WRN). Primary tail fibroblast cultures from K577M-WRN mice showed three characteristics of WS cells: hypersensitivity to 4-nitroquinoline-1-oxide (4NQO), reduced replicative potential, and reduced expression of the endogenous WRN protein. These data suggest that K577M-WRN mice may provide a novel mouse model for the WS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.