ArticleGenetics2000
A genetic test to determine the origin of maternal transmission ratio distortion. Meiotic drive at the mouse Om locus.
Article in Genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- A systematic review and critical analysis of the evidence for transmission ratio distortion in humans.Genetics · 2026Pooled it
- Is there a Mendelian transmission ratio distortion of the c.429_452dup(24bp) polyalanine tract ARX mutation?European journal of human genetics : EJHG · 2012Pooled it
- Meiotic drive of noncentromeric loci in mammalian meiosis II eggs.Current opinion in genetics & development · 2023Review
- Unravelling transmission ratio distortion across the bovine genome: identification of candidate regions for reproduction defects.BMC genomics · 2023Article
- Bypassing Mendel's First Law: Transmission Ratio Distortion in Mammals.International journal of molecular sciences · 2023Review
- Article
- Whole-genome resequencing reveals loci with allelic transmission ratio distortion in FMolecular genetics and genomics : MGG · 2021Article
- Discovering lethal alleles across the turkey genome using a transmission ratio distortion approach.Animal genetics · 2020Article
- Article
- Non-human Primate Schlafen11 Inhibits Production of Both Host and Viral Proteins.PLoS pathogens · 2016Article
- Article
- Article
- Genetic mapping and developmental timing of transmission ratio distortion in a mouse interspecific backcross.BMC genetics · 2010Article
- Article
- Characterization of two Mst1-deficient mouse models.Developmental dynamics : an official publication of the American Association of Anatomists · 2008Article
- Cytonuclear genic incompatibilities cause increased mortality in male F2 hybrids of Nasonia giraulti and N. vitripennis.Genetics · 2008Article
- Constructing the parental linkage phase and the genetic map over distances <1 cM using pooled haploid DNA.Genetics · 2006Article
- An investigation of transmission ratio distortion in the central region of the human MHC.Genes and immunity · 2006Article
- The paternal gene of the DDK syndrome maps to the Schlafen gene cluster on mouse chromosome 11.Genetics · 2006Article
- Maternal transmission ratio distortion at the mouse Om locus results from meiotic drive at the second meiotic division.Genetics · 2005Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We have shown previously that the progeny of crosses between heterozygous females and C57BL/6 males show transmission ratio distortion at the Om locus on mouse chromosome 11. This result has been replicated in several independent experiments. Here we show that the distortion maps to a single locus on chromosome 11, closely linked to Om, and that gene conversion is not implicated in the origin of this phenomenon. To further investigate the origin of the transmission ratio distortion we generated a test using the well-known effect of recombination on maternal meiotic drive. The genetic test presented here discriminates between unequal segregation of alleles during meiosis and lethality, based on the analysis of genotype at both the distorted locus and the centromere of the same chromosome. We used this test to determine the cause of the transmission ratio distortion observed at the Om locus. Our results indicate that transmission ratio distortion at Om is due to unequal segregation of alleles to the polar body at the second meiotic division. Because the presence of segregation distortion at Om also depends on the genotype of the sire, our results confirm that the sperm can influence segregation of maternal chromosomes to the second polar body.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.